pict_left_area_17

Two BRUKER 11.746 T superconducting actively shielded magnets (UltraShieldPlus), 5 mm BBO probe with z-axis gradient and automated tuning and matching (ATM), 5 mm BBI probe with z-axis gradient and ATM, 1 mm TXI probe (1H,13C,15N) with z-axis gradient and ATM, BCU 05 cooling unit, TopSpin

The Institute of Inorganic Chemistry possesses a Bruker X8 APEXII CCD diffractometer equipped with a M86-E00034 Kryo-Flex Low Temperatur Device (Temperatur Range: 90K-300K) for determination of crystal structures of small molecules.

Cellculture equipment

ICP-MS (Agilent 7500ce)  

ICP-QQQ-MS (Agilent 8800)  

ESI-MS (Bruker Amazon SL) 

For the purification of synthesized compounds the Institute of Inorganic Chemistry provides an Agilent 1200 Series Prep HPLC system with RP and NP columns controlled by ChemStation software.

HPLC (Dionex Ultimate 3000 RS) Amongst others, this UHPLC-capable Ultimate 3000 RS is being used to determine the lipophilicity of developmental Metallodrugs as well as for quality control of synthesis products.

Laser (New Wave, ESI)  The laser ablation unit can be hyphenated to the ICP-MS instruments and allows to obtain space-resolved information on total metal contents in mouse organs or extravasates. This may help to draw conclusions on possible toxic effects in in vivo experiments. Additionally, a quantification strategy is being developed.

Capillary electrophoresis (Agilent G7100) The Agilent CE G7100 is a research instrument for characterizing metallodrugs and investigation on hydrolysis pathways as well as interaction with DNA in aqueous solution are currently the main topics. The analytes are being detected either by the in-built UV-cell or by hyphenating the instrument to either the ESI- or the ICP-mass spectrometer.

UV-VIS

IR

TG

Zeeman-AAS

GC

TOC-Analizer

Facilities in Environmental and Radiochemistry

UV-VIS Spectrometer Lambda

GF-AAS

CV-AAS FIMS

IC Dionex IC 1000

Flammen AAS

TC TN Analyzer

Freeze Dryer

GC-MS Clarus 500

Two BRUKER FT-NMR Spektromer Avance III 500 MHz with UltraShieldPlus-Magnetsystem