Nucleic Acid Chemistry

The research focus is nucleic acid chemistry, particularly as related to the in situ light-directed synthesis of RNA and DRNA microarrays for both genomic and non-genomic applications. The RNA microarrays have applications in the discovery and study of protein-RNA interactions, RNase specificity and kinetics, RNA interference, structure-function relationships of riboswitches, etc.

The DNA microarrays are used both in traditional applications, such as measuring gene and miRNA expression, but also for non-genomic  uses, including aptamer microarrays for analyte detection and for high-throughput determination of fluorophore-DNA interactions, such as charge transfer.

Because this research requires close control and a detailed understanding of photochemistry and phosphoramidite chemistry on surfaces, we also develop these areas. Of particular interest are: testing and optimizing new photolabile groups, improving phosphoramidite coupling and overall synthesis efficiency, and the development of analytical methods to assess the purity of oligonucleotides synthesized on microarrays.

Assoz. Prof. Mark Somoza PhD




Tel: +43 1 4277 52643 

1090 Wien, Althanstraße 14; UZA 2
Zimmer 2A553