Publications 2013


Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes
Valiahdi, S. M., Egger, A., Miklos, W., Jungwirth, U., Meelich, K., Berger, W., Hartinger, C. G., Galanski, M., Jakupec, M. & Keppler, B.
Journal of Biological Inorganic Chemistry (2013) 18, 2, 249-260

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery
Pichler, V., Mayr, J., Heffeter, P., Domotor, O., Enyedy, E. A., Hermann, G., Groza, D., Köllensperger, G., Galanski, M., Berger, W., Keppler, B. & Kowol, C.
Chemical Communications (2013) 49, 22, 2249-2251

Synthesis, radiosynthesis and first in vitro evaluation of novel PET-tracers for the dopamine transporter: [C-11]IPCIT and [F-18]FE@IPCIT
Rami-Mark, C., Bornatowicz, B., Fink, C., Otter, P., Ungersboeck, J., Vraka, C., Haeusler, D., Nics, L., Spreitzer, H., Hacker, M., Mitterhauser, M. & Wadsak, W.

Bioorganic & Medicinal Chemistry (
2013) 21, 24, 7562-7569

Reliable set-up for in-loop C-11-carboxylations using Grignard reactions for the preparation of [carbonyl-C-11]WAY-100635 and [C-11]-(+)-PHNO
Rami-Mark, C., Ungersboeck, J., Haeusler, D., Nics, L., Philippe, C., Mitterhauser, M., Willeit, M., Lanzenberger, R., Karanikas, G. & Wadsak, W.
Applied Radiation and Isotopes (2013) 82, 75-80

Determination of absolute configuration of the phosphonic acid moiety of fosfazinomycins
Schiessl, K., Roller, A. & Hammerschmidt, F.
Organic & Biomolecular Chemistry (2013) 11, 42, 7420-7426

[F-18]FMeNER-D2: Reliable fully-automated synthesis for visualization of the norepinephrine transporter
Rami-Mark, C., Zhang, M-R., Mitterhauser, M., Lanzenberger, R., Hacker, M. & Wadsak, W.
Nuclear Medicine and Biology (2013) 40, 8, 1049-1054

Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway
Rohm, B., Holik, A-K., Somoza, M. M., Pignitter, M., Zaunschirm, M., Ley, J. P., Krammer, G. E. & Somoza, V.
Molecular Nutrition & Food Research (2013) 57, 11, 2008-2018

Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes
Hanif, M., Meier, S. M., Nazarov, A. A., Risse, J., Legin, A., Casini, A., Jakupec, M., Keppler, B. & Hartinger, C. G.
Frontiers in Chemistry (2013) 1, 27

Major and trace element geochemistry of Lake Bogoria and Lake Nakuru, Kenya, during extreme draught
Jirsa, F., Gruber, M., Stojanovic, A., Oduor, S. O., Mader, D., Körner, W. & Schagerl, M.
Chemie der Erde / Geochemistry (2013) 73, 3, 275-282

Preclinical in vitro & in vivo evaluation of [C-11]SNAP-7941-the first PET tracer for the melanin concentrating hormone receptor 1
Philippe, C., Nics, L., Zeilinger, M., Kuntner, C., Wanek, T., Mairinger, S., Shanab, K., Spreitzer, H., Viernstein, H., Wadsak, W. & Mitterhauser, M.
Nuclear Medicine and Biology (2013) 40, 7, 919-925

Solution equilibria of anticancer ruthenium(II)-(eta(6)-p-cymene)-hydroxy(thio)pyr(id) one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity
Enyedy, E. A., Sija, E., Jakusch, T., Hartinger, C. G., Kandioller, W., Keppler, B. K. & Kiss, T.
Journal of Inorganic Biochemistry (2013) 127, 161-168

Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [C-11]SNAP-7941 and [F-18]FE@SNAP for Positron Emission Tomography
Schirmer, E., Shanab, K., Datterl, B., Neudorfer, C., Mitterhauser, M., Wadsak, W., Philippe, C. & Spreitzer, H.
Molecules (2013) 18, 10, 12119-12143

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
Heffeter, P., Atil, B., Kryeziu, K., Groza, D., Koellensperger, G., Koerner, W., Jungwirth, U., Mohr, T., Keppler, B. K. & Berger, W.
European Journal of Cancer (2013) 49, 15,  3366-3375

New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3-and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity
Ivanovic, I., Gligorijevic, N., Arandelovic, S., Radulovic, S., Roller, A., Keppler, B. K., Tesic, Z. L. & Grguric-Sipka, S.
Polyhedron (2013) 61, 112-118

Simultaneous Light-Directed Synthesis of Mirror-Image Microarrays in a Photochemical Reaction Cell with Flare Suppression
Sack, M., Kretschy, N., Rohm, B., Somoza, V. & Somoza, M. M.
Analytical Chemistry (2013) 85, 18, 8513-8517

Dicopper(II) and Dizinc(II) Complexes with Nonsymmetric Dinucleating Ligands Based on Indolo[3,2-c]quinolines: Synthesis, Structure, Cytotoxicity, and Intracellular Distribution
Primik, M. F., Goeschl, S., Meier, S. M., Eberherr, N., Jakupec, M. A., Enyedy, E. A., Novitchi, G. & Arion, V. B.
Inorganic Chemistry (2013) 52, 17, 10137-10146

p53 Increases Intra-Cellular Calcium Release by Transcriptional Regulation of Calcium Channel TRPC6 in GaQ(3)-Treated Cancer Cells
Madan, E., Gogna, R., Keppler, B. & Pati, U.
PLoS ONE (2013) 8, 8, 71016

Copper(II) Complexes with Highly Water-Soluble L- and D-Proline-Thiosemicarbazone Conjugates as Potential Inhibitors of Topoisomerase II alpha
Bacher, F., Enyedy, E. A., Nagy, N. V., Rockenbauer, A., Bognar, G. M., Trondl, R., Novak, M. S., Klapproth, E., Kiss, T. & Arion, V. B.
Inorganic Chemistry (2013) 52, 15, 8895-8908

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2 '-deoxyguanosine 5'-monophosphate (dGMP)
Grabmann, G., Keppler, B. K. & Hartinger, C. G.
Analytical and Bioanalytical Chemistry (2013) 405, 20, 6417-6424

Bulky N(,N)-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes
Pichler, V., Goeschl, S., Meier, S. M., Roller, A., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Inorganic Chemistry (2013) 52, 14, 8151-8162

Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate
Meier, S. M., Novak, M., Kandioller, W., Jakupec, M. A., Arion, V. B., Metzler-Nolte, N., Keppler, B. K. & Hartinger, C. G.
Chemistry: A European Journal (2013) 19, 28, 9297-9307

Marked stabilization of redox states and enhanced catalytic activity in galactose oxidase models based on transition metal S- methylisothiosemicarbazonates with -SR group in ortho position to the phenolic oxygen
Arion, V. B., Platzer, S., Rapta, P., Machata, P., Breza, M., Vegh, D., Dunsch, L., Telser, J., Shova, S., Mac Leod, T. C. O. & Pombeiro, A. J. L.
Inorganic Chemistry (2013) 52, 13, 7524-7540

Osmium-nitrosyl complexes with glycine, picolinic acid, L -proline and D -proline: Synthesis, structures and antiproliferative activity
Gavriluta, A., Novak, M., Tommasino, J. B., Meier, S. M., Jakupec, M. A., Luneau, D. & Arion, V. B.
Zeitschrift für Anorganische und Allgemeine Chemie (2013) 639, 8-9, 1590-1597

Platinum(IV) Complexes Featuring Axial (1,4-C-13(2))Succinato Ligands - Synthesis, Characterization, and Preliminary Investigations in Cancer Cell Lysates
Banfic, J., Adib Razavi, M. S., Galanski, M. & Keppler, B. K.
Zeitschrift für Anorganische und Allgemeine Chemie (2013)
639, 8-9, 1613-1620

Rhodium(Cp*) Compounds with Flavone-derived Ligand Systems: Synthesis and Characterization
Schwarz, M. B., Kurzwernhart, A., Roller, A., Kandioller, W., Keppler, B. K. & Hartinger, C. G.
Zeitschrift für Anorganische und Allgemeine Chemie (2013) 639, 8-9, 1648-1654

Natural organic matter and iron export from the Tanner Moor, Austria
Jirsa, F., Neubauer, E., Kittinger, R., Hofmann, T., Krachler, R., von der Kammer, F. & Keppler, B.
Limnologica (2013) 43, 4, 239-244

Investigation of the isotopic ratio I-129/I in petrified wood
Jabbar, T., Steier, P., Wallner, G., Cichocki, O. & Sterba, J. H.
Journal of Environmental Radioactivity (2013)
120, 33-38

Development and automation of a novel NET-PET tracer: [C-11]Me@APPI
Mark, C., Bornatowicz, B., Mitterhauser, M., Hendl, M., Nics, L., Häusler, D., Lanzenberger, R., Berger, M. L., Spreitzer, H. & Wadsak, W.
Nuclear Medicine and Biology (2013) 40, 2, 295-303

U-236/U-238 and Pu-240/Pu-239 isotopic ratios in small (2 L) sea and river water samples
Eigl, R., Srncik, M., Steier, P. & Wallner, G.
Journal of Environmental Radioactivity (2013) 116, 54-58

A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors
Dobrov, A., Goeschl, S., Jakupec, M. A., Popovic-Bijelic, A., Graslund, A., Rapta, P. & Arion, V. B.
Chemical Communications (2013) 49, 85, 10007-10009

Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development
Babak, M., Meier, S. M., Legin, A., Adib Razavi, M. S., Roller, A., Jakupec, M., Keppler, B. & Hartinger, C. G.
Chemistry: A European Journal (2013)
19, 13, 4308-4318

AMS of the Minor Plutonium Isotopes
Steier, P., Hrnecek, E., Priller, A., Quinto, F., Srncik, M., Wallner, A., Wallner, G. & Winkler, S.
Nuclear Instruments & Methods in Physics Research. Section B. Beam Interactions with Materials and Atoms (2013) 294, 160-164

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies
Domotor, O., Hartinger, C. G., Bytzek, A., Kiss, T., Keppler, B. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2013) 18, 1, 9-17

Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics
Kupcewicz, B., Sobiesiak, K., Malinowska, K., Koprowska, K., Czyz, M., Keppler, B. & Budzisz, E.
Medicinal Chemistry Research (2013) 22, 5, 2395-2402

Copper(II) Complexes with Schiff Bases Containing a Disiloxane Unit: Synthesis, Structure, Bonding Features and Catalytic Activity for Aerobic Oxidation of Benzyl Alcohol
Soroceanu, A., Cazacu, M., Shova, S., Turta, C., Kozisek, J., Gall, M., Breza, M., Rapta, P., Mac Leod, T. C. O., Pombeiro, A. J. L., Telser, J., Dobrov, A. & Arion, V.
European Journal of Inorganic Chemistry (2013) 9, 1458-1474

Cytotoxic activities of phytochemicals from Ferula species
Valiahdi, S. M., Iranshahi, M. & Sahebkar, A.
DARU-Journal of Pharmaceutical Sciences (2013) 21

Hexanuclear and undecanuclear iron(III) carboxylates as catalyst precursors for cyclohexane oxidation
Milunovic, M. N. M., Martins, L. M. D. R. S., Alegria, E. C. B. A., Pombeiro, A. J. L., Krachler, R., Trettenhahn, G., Turta, C., Shova, S. & Arion, V. B.
Dalton Transactions (Print Edition) (2013) 42, 40, 14388-14401

[H-3]Metyrapol and 4-[I-131]Iodometomidate Label Overlapping, but Not Identical, Binding Sites on Rat Adrenal Membranes
Berger, M. L., Hammerschmidt, F., Qian, R., Hahner, S., Schirbel, A., Stichelberger, M., Schibli, R., Yu, J., Arion, V. & Zolle, I. M.
Molecular Pharmaceutics (2013) 10, 3, 1119-1130

Mechanism Elucidation of the cis-trans Isomerization of an Azole Ruthenium-Nitrosyl Complex and Its Osmium Counterpart
Gavriluta, A., Büchel, G., Freitag, L., Novitchi, G., Tommasino, J. B., Jeanneau, E., Kuhn, P-S., Gonzalez Herrero, L., Arion, V. & Luneau, D.
Inorganic Chemistry (2013) 52, 11, 6260-6272

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
Filak, L., Göschl, S., Heffeter, P., Egger, A., Jakupec, M., Keppler, B., Berger, W. & Arion, V.
Organometallics (2013) 32, 3, 903-914

N-ε-Carboxymethyllysine (CML), a Maillard reaction product, stimulates serotonin release and activates the receptor for advanced glycation end products (RAGE) in SH-SY5Y cells
Holik, A-K., Rohm, B., Somoza, M. M. & Somoza, V.
Food & Function (2013) 4, 7, 1111-1120

Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
Meier, S. M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M., Arion, V., Davey, C. A., Keppler, B. & Hartinger, C.
Chemical Science (2013) 4, 4, 1837-1846

On the Electronic Structure of mer,trans-[RuCl3(1H-indazole)2(NO)], a Hypothetical Metabolite of the Antitumor Drug Candidate KP1019: An Experimental and DFT Study
Bucinsky, L., Büchel, G., Ponec, R., Rapta, P., Breza, M., Kozisek, J., Gall, M., Biskupic, S., Fronc, M., Schiessl, K., Cuzan, O., Prodius, D., Turta, C., Shova, S., Zajac, D. A. & Arion, V.
European Journal of Inorganic Chemistry (2013) 14, 2505-2519

Optimized Light-Directed Synthesis of Aptamer Microarrays
Franssen-van Hal, N. L. W., van der Putte, P., Hellmuth, K., Matysiak, S., Kretschy, N. & Somoza, M. M.
Analytical Chemistry (2013) 85, 12, 5950-5957

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
Kandioller, W., Balsano, E., Meier, S. M., Jungwirth, U., Göschl, S., Roller, A., Jakupec, M., Berger, W., Keppler, B. & Hartinger, C. G.
Chemical Communications (2013) 49, 32, 3348-3350

Solution equilibrium studies on anticancer ruthenium(II)-eta(6)-p-cymene complexes of 3-hydroxy-2(1H)-pyridones
Enyedy, E. A., Bognar, G. M., Kiss, T. & Hartinger, C.
Journal of Organometallic Chemistry (2013) 734, SI, 38-44

Striking Difference in Antiproliferative Activity of Ruthenium- and Osmium-Nitrosyl Complexes with Azole Heterocycles
Büchel, G., Gavriluta, A., Novak, M., Meier, S. M., Jakupec, M., Cuzan, O., Turta, C., Tommasino, J. B., Jeanneau, E., Novitchi, G., Luneau, D. & Arion, V.
Inorganic Chemistry (2013) 52, 11, 6273-6285

Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Kryeziu, K., Jungwirth, U., Hoda, M. A., Ferk, F., Karnthaler-Benbakka, C., Knasmüller, S., Kowol, C., Berger, W. & Heffeter, P.
Molecular Cancer Therapeutics (2013) 12, 6, 1073-1084

Theoretical Investigations and Density Functional Theory Based Quantitative Structure-Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes
Varbanov, H., Jakupec, M., Roller, A., Jensen, F., Galanski, M. & Keppler, B.
Journal of Medicinal Chemistry (2013) 56, 1, 330-344

X-ray Absorption Near Edge Structure Spectroscopy to Resolve the in Vivo Chemistry of the Redox-Active Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019)
Hummer, A., Heffeter, P., Berger, W., Filipits, M., Batchelor, D., Büchel, G., Jakupec, M., Keppler, B. & Rompel, A.
Journal of Medicinal Chemistry (2013) 56, 3, 1182-1196

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru-II(arene) anticancer complexes with biologically active ligands
Kurzwernhart, A., Kandioller, W., Enyedy, E. A., Novak, M., Jakupec, M., Keppler, B. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2013) 42, 17, 6193-6202

A review on I-129 analysis in air
Jabbar, T., Wallner, G. & Steier, P.
Journal of Environmental Radioactivity (2013) 126, 45-54

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
Hartinger, C. G., Größl, M., Meier, S. M., Casini, A. & Dyson, P. J.
Chemical Society Reviews (2013) 42, 14, 6186-6199