Publications 2016


Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
Miklos, W., Heffeter, P., Pirker, C., Hager, S., Kowol, C. R., van Schoonhoven, S., Stojanovic, M., Keppler, B. K. & Berger, W.
Onco Target (2016) 7, 51, 84556-84574

DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives
Bonsignore, R., Notaro, A., Salvo, A. M. P., Spinello, A., Fiasconaro, G., Terenzi, A., Giacalone, F., Keppler, B., Giuliano, M., Gruttadauria, M. & Barone, G.
Chemistry SELECT (2016) 1, 21, 6755–6761

Synthesis and Characterization of the First Nickel(II)-Centered Single-Side Tris-Functionalized Anderson-Type Polyoxomolybdate
Gumerova, N., Roller, A. & Rompel, A.
European Journal of Inorganic Chemistry (2016), 36,  5507-5511

Anticancer metal drugs and immunogenic cell death
Terenzi, A., Pirker, C., Keppler, B. K. & Berger, W.
Journal of Inorganic Biochemistry (2016) 165, 71-79

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior
Hackl, C. M., Legina, M. S., Pichler, V., Schmidlehner, M., Roller, A., Domotor, O., Enyedy, E. A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2016) 22, 48, 17269-17281

Iron(II) Complexes Containing Chiral Unsymmetrical PNP ' Pincer Ligands: Synthesis and Application in Asymmetric Hydrogenations
Zirakzadeh, A., Kirchner, K., Roller, A., Stoeger, B., Widhalm, M. & Morris, R. H.
Organometallics (2016) 35, 21, 3781-3787

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs
Karnthaler-Benbakka, C., Groza, D., Koblmueller, B., Terenzi, A., Holste, K., Haider, M., Baier, D., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
ChemMedChem (2016) 11, 21, 2410-2421

Associated effects of storage and mechanical pre-treatments of microalgae biomass on biomethane yields in anaerobic digestion
Gruber-Brunhumer, M. R., Jerney, J., Zohar, E., Nussbaumer, M., Hieger, C., Bromberger, P., Bochmann, G., Jirsa, F., Schagerl, M., Obbard, J. P., Fuchs, W. & Drosg, B.
Biomass & Bioenergy (2016) 93, 259-268

N ϵ -Carboxymethyllysine Increases the Expression of miR-103/143 and Enhances Lipid Accumulation in 3T3-L1 Cells
Holik, A-K., Lieder, B., Kretschy, N., Somoza, M. M., Held, S. & Somoza, V.
Journal of Cellular Biochemistry (2016) 117, 10, 2413-2422

Vanadium(V) Complexes with Substituted 1,5-bis(2-hydroxybenzaldehyde)carbohydrazones and Their Use As Catalyst Precursors in Oxidation of Cyclohexane
Dragancea, D., Talmaci, N., Shova, S., Novitchi, G., Darvasiova, D., Rapta, P., Breza, M., Galanski, M., Kozisek, J., Martins, N. M. R., Martins, L. M. D. R. S., Pombeiro, A. J. L. & Arion, V. B.
Inorganic Chemistry (2016) 55, 18, 9187-9203

Synthesis, characterisation and cytotoxic activity of organoruthenium(II)-halido complexes with 1H-benzimidazole-2-carboxylic acid
Pantic, D. N., Arandelovic, S., Radulovic, S., Roller, A., Arion, V. B. & Grguric-Sipka, S.
Journal of Organometallic Chemistry (2016) 819, 61-68 8

Structure-antiproliferative activity studies on L-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(II), palladium(II) and copper(II) complexes
Dobrova, A., Platzer, S., Bacher, F., Milunovic, M. N. M., Dobrov, A., Spengler, G., Enyedy, E. A., Novitchi, G. & Arion, V. B.
Dalton Transactions (Print Edition) (2016) 45, 34, 13427-13439

Oxime-Bridged Mn-6 Clusters Inserted in One-Dimensional Coordination Polymer
Zaltariov, M-F., Cazacu, M., Sacarescu, L., Vlad, A., Novitchi, G., Train, C., Shova, S. & Arion, V. B.Macromolecules (2016) 49, 17, 6163-6172

New tartrate based cyclic phosphoric acids as organocatalysts in Mannich reactions
Budragchaa, T., Abraham, M., Schöfberger, W., Roller, A. & Widhalm, M.
Asymmetric Catalysis (2016) 3, 1

Towards targeting anticancer drugs: ruthenium(II)-arene complexes with biologically active naphthoquinone-derived ligand systems
Kubanik, M., Kandioller, W., Kim, K., Anderson, R. F., Klapproth, E., Jakupec, M. A., Roller, A., Sohnel, T., Keppler, B. K. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2016) 45, 33, 13091-13103

Synthesis, structure, and antioxidant activity of methoxy- and hydroxyl-substituted 2'-aminochalcones
Sulpizio, C., Roller, A., Giester, G. & Rompel, A.
Chemical Monthly (2016) 147, 10, 1747-1757

Novel thiosalicylate-based ionic liquids for heavy metal extractions
Leyma, R. M., Platzer, S., Jirsa, F., Kandioller, W., Krachler, R. & Keppler, B.
Journal of Hazardous Materials (2016) 314, 164-171

[F-18]FMeNER-D2: A systematic in vitro analysis of radio-metabolism
Rami-Mark, C., Eberherr, N., Berroteran-Infante, N., Vanicek, T., Nics, L., Lanzenberger, R., Hacker, M., Wadsak, W. & Mitterhauser, M.
Nuclear Medicine and Biology (2016) 43, 8, 490-495

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes
Bonsignore, R., Terenzi, A., Spinello, A., Martorana, A., Lauria, A., Almerico, A. M., Keppler, B. K. & Barone, G.
Journal of Inorganic Biochemistry (2016) 161, 115-121

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes
Henke, H., Kryeziu, K., Banfic, J., Theiner, S., Körner, W., Brueggemann, O., Berger, W., Keppler, B., Heffeter, P. & Teasdale, I.
Macromolecular Bioscience (2016) 16, 8, 1239-1249

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention
Kowol, C. R., Miklos, W., Pfaff, S., Hager, S., Kallus, S., Pelivan, K., Kubanik, M., Enyedy, E. A., Berger, W., Heffeter, P. & Keppler, B. K.
Journal of Medicinal Chemistry (2016) 59, 14, 6739-6752

Biodistribution of the novel anticancer drug sodium trans-Retrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
Bytzek, A. K., Koellensperger, G., Keppler, B. K. & Hartinger, C. G.
Journal of Inorganic Biochemistry (2016) 160, 250-255

Differences in protein binding and excretion of Triapine and its Fe(III) complex
Pelivan, K., Miklos, W., Van Schoonhoven, S., Köllensperger, G., Gille, L., Berger, W., Heffeter, P., Kowol, C. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 61-69

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs
Göschl, S., Varbanov, H., Theiner, S., Jakupec, M., Galanski, M. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 264-274

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
Bijelic, A., Theiner, S., Keppler, B. K. & Rompel, A.
Journal of Medicinal Chemistry (2016) 59, 12, 5894-5903

Sphagnum-dominated bog systems are highly effective yet variable sources of bio-available iron to marine waters
Krachler, R., Krachler, R., Wallner, G., Steier, P., El Abiead, Y., Wiesinger, H., Jirsa, F. & Keppler, B.
Science of the Total Environment (2016) 556, 53-62

Synthesis of Indolophanes by Photochemical Macrocyclization
Pfaffenbach, M., Roller, A. & Gaich, T.
Chemistry: A European Journal (2016) 22, 25, 8444-8447

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
Novak, M. S., Buechel, G. E., Keppler, B. K. & Jakupec, M. A.
Journal of Biological Inorganic Chemistry (2016) 21, 3, 347-356

Evaluation of Palm Oil as a Suitable Vegetable Oil for Vitamin A Fortification Programs
Pignitter, M., Hernler, N., Zaunschirm, M., Kienesberger, J., Somoza, M. M., Kraemer, K. & Somoza, V.
Nutrients (2016) 8, 6, 378

Investigation of the binding of cis/trans-[MCl4(1H-indazole)(NO)](-) (M = Ru, Os) complexes to human serum albumin
Domotor, O., Rathgeb, A., Kuhn, P-S., Popovic-Bijelic, A., Bacic, G., Enyedy, E. A. & Arion, V. B.
Journal of Inorganic Biochemistry (2016) 159, 37-44

Molecular mode of action of NKP-1339-a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines
Flocke, L. S., Trondl, R., Jakupec, M. A. & Keppler, B. K.
Investigational New Drugs (2016) 34, 3, 261-268

Photoreduction of Terrigenous Fe-Humic Substances Leads to Bioavailable Iron in Oceans
Blazevic, A., Orlowska, E., Kandioller, W., Jirsa, F., Keppler, B. K., Tafili-Kryeziu, M., Linert, W., Krachler, R. F., Krachler, R. & Rompel, A.
Angewandte Chemie (International Edition) (2016) 55, 22, 6417-6422

Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects
Meier, S. M., Gerner, C., Keppler, B. K., Cinellu, M. A. & Casini, A.
Inorganic Chemistry (2016) 55, 9, 4248-4259

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
Schreiber-Brynzak, E., Pichler, V., Heffeter, P., Hanson, B., Theiner, S., Lichtscheidl-Schultz, I., Kornauth, C., Bamonti, L., Dhery, V., Groza, D., Berry, D., Berger, W., Galanski, M., Jakupec, M. A. & Keppler, B. K.
Metallomics (2016) 8, 4, 422-433

Determination of size-dependent metal distribution in dissolved organic matter by SEC-UV/VIS-ICP-MS with special focus on changes in seawater
Rathgeb, A., Causon, T., Krachler, R. & Hann, S.
Electrophoresis (2016) 37, 7-8, 1063-1071

Ruthenium Carbonyl Complexes with Azole Heterocycles - Synthesis, X-ray Diffraction Structures, DFT Calculations, Solution Behavior, and Antiproliferative Activity
Kuhn, P-S., Meier, S. M., Jovanovic, K. K., Sandler, I., Freitag, L., Novitchi, G., Gonzalez, L., Radulovic, S. & Arion, V. B.
European Journal of Inorganic Chemistry (2016) 10, 1566-1576     

Trace element accumulation and human health risk assessment of Labeo capensis (Smith, 1841) from the Vaal Dam reservoir, South Africa
Lynch, L. P., Jirsa, F. & Avenant-Oldewage, A.
Water SA (2016) 42, 2, 328-336

Circular Dichroism of DNA G-Quadruplexes: Combining Modeling and Spectroscopy To Unravel Complex Structures
Gattuso, H., Spinello, A., Terenzi, A., Assfeld, X., Barone, G. & Monari, A.
The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical (2016) 120, 12, 3113-3121

Express photolithographic DNA microarray synthesis with optimized chemistry and high-efficiency photolabile groups
Sack, M., Hoelz, K., Holik, A-K., Kretschy, N., Somoza, V., Stengele, K-P. & Somoza, M. M.
Journal of Nanobiotechnology (2016) 14, 13, 14

Prediction of logP for Pt(II) and Pt(IV) complexes: Comparison of statistical and quantum-chemistry based approaches
Tetko, I. V., Varbanov, H. P., Galanski, M., Talmaciu, M., Platts, J. A., Ravera, M. & Gabano, E.
Journal of Inorganic Biochemistry (2016) 156, 1-13

Sequence-Dependent Fluorescence of Cy3-and Cy5-Labeled Double-Stranded DNA
Kretschy, N., Sack, M. & Somoza, M. M.
Bioconjugate Chemistry (2016) 27, 3, 840-848

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH)
Garbutcheon-Singh, K. B., Galanski, M., Keppler, B. K. & Aldrich-Wright, J. R.
Inorganica Chimica Acta (2016) 441, 152-156

Teaching Inorganic Photophysics and Photochemistry with Three Ruthenium(II) Polypyridyl Complexes: A Computer-Based Exercise
Garino, C., Terenzi, A., Barone, G. & Salassa, L.
Journal of Chemical Education (2016) 93, 2, 292-298

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Wilfinger, N., Austin, S., Scheiber-Mojdekhar, B., Berger, W., Reipert, S., Praschberger, M., Paur, J., Trondl, R., Keppler, B. K., Zielinski, C. C. & Nowikovsky, K.
Onco Target (2016) 7, 2, 1242-1261

European roe deer antlers as an environmental archive for fallout U-236 and Pu-239
Froehlich, M. B., Steier, P., Wallner, G. & Fifield, L. K.
Journal of Environmental Radioactivity (2016) 151, 587-592

Flavonoid-Based Organometallics with Different Metal Centers - Investigations of the Effects on Reactivity and Cytotoxicity
Kurzwernhart, A., Mokesch, S., Klapproth, E., Adib Razavi, M. S., Jakupec, M. A., Hartinger, C. G., Kandioller, W. & Keppler, B. K.
European Journal of Inorganic Chemistry (2016) 2, 240-246

Absolute configuration of the antimalarial erythro-mefloquine - vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative
Kohout, M., Vandenbussche, J., Roller, A., Tuma, J., Bogaerts, J., Bultinck, P., Herrebout, W. & Lindner, W.
RSC Advances (2016) 6, 85, 81461-81465     

Accurate high throughput quantification of selenium in biological samples - the potential of combining isotope dilution ICP-tandem mass spectrometry with flow injection
Bamonti, L., Theiner, S., Rohr-Udilova, N., Keppler, B. K. & Koellensperger, G.
Journal of Analytical Atomic Spectrometry (2016) 31, 11, 2227-2232

Another step toward DNA selective targeting: Ni-II and Cu-II complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
Terenzi, A., Loetsch, D., van Schoonhoven, S., Roller, A., Kowol, C. R., Berger, W., Keppler, B. K. & Barone, G.
Dalton Transactions (Print Edition) (2016) 45, 18, 7758-7767     

Benzoic hydroxamate-based iron complexes as model compounds for humic substances: synthesis, characterization and algal growth experiments
Orlowska, E., Roller, A., Wiesinger, H., Pignitter, M., Jirsa, F., Krachler, R., Kandioller, W. & Keppler, B.
RSC Advances (2016) 6, 46, 40238-40249

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics
Schmidlehner, M., Flocke, L. S., Roller, A., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2016) 45, 2, 724-733     

KINFix - A formalin-free non-commercial fixative optimized for histological, immunohistochemical and molecular analyses of neurosurgical tissue specimens
Stefanits, H., Bienkowski, M., Galanski, M., Mitulovic, G., Stroebel, T., Gelpi, E., Ribalta, T., Broholm, H., Hartmann, C., Kros, J. M., Preusser, M. & Hainfellner, J. A.
Clinical neuropathology (2016) 35, 1, 3-12

LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G. & Keppler, B. K.
Metallomics (2016) 8, 4, 398-402

Multi-scale imaging of anticancer platinum(IV) compounds in murine tumor and kidney
Legin, A. A., Theiner, S., Schintlmeister, A., Reipert, S., Heffeter, P., Jakupec, M. A., Mayr, J., Varbanov, H. P., Kowol, C. R., Galanski, M., Berger, W., Wagner, M. & Keppler, B. K.
Chemical Science (2016) 7, 5, 3052-3061

Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity
Fischer, B., Kryeziu, K., Kallus, S., Heffeter, P., Berger, W., Kowol, C. R. & Keppler, B. K.
RSC Advances (2016) 6, 61, 55848-55859     

[Ni(OH)(3)W6O18(OCH2)(3)CCH2OH](4-): the first tris-functionalized Anderson-type heteropolytungstate
Gumerova, N. I., Roller, A. & Rompel, A.
Chemical Communications (2016) 52, 59, 9263-9266     

Synthesis, coordination behavior and structural features of chiral iron(II) PNP diferrocene complexes
Zirakzadeh, A., Kirchner, K., Roller, A., Stoeger, B., Carvalho, M. D. & Ferreira, L. P.
RSC Advances  (2016) 6, 14, 11840-11847

Turbulent flow chromatography in combination with HPLC-ICP-MS for high-throughput analysis of free, intact metal based drugs in biomedical samples
Koellensperger, G., Galanski, M., Keppler, B. K. & Hann, S.
Journal of Analytical Atomic Spectrometry (2016) 31, 9, 1811-1817

Electrophoretic separation techniques and their hyphenation to mass spectrometry in biological inorganic chemistry
Holtkamp, H., Grabmann, G. & Hartinger, C. G. Apr 2016
Electrophoresis (2016) 37, 7-8, 959-972

Metal Ions and Metal Complexes in Alzheimer's Disease
Spinello, A., Bonsignore, R., Barone, G., Keppler, B. K. & Terenzi, A.
Current Pharmaceutical Design (2016) 22, 26, 3996-4010