Publications 2020

u:cris

An ICP-MS-based assay for characterization of gold nanoparticles with potential biomedical use
Kuznetsova, O., Rubio, G. M. D. M., Keppler, B. K., Chin, J. M., Reithofer, M. R. & Timerbaev, A. R.
Analytical Biochemistry (2020) 611, 114003

MR Imaging of Peripheral Nerves Using Targeted Application of Contrast Agents: An Experimental Proof-of-Concept Study
Tereshenko, V., Pashkunova-Martic, I., Manzano-Szalai, K., Friske, J., Bergmeister, K. D., Festin, C., Aman, M., Hruby, L. A., Klepetko, J., Theiner, S., Klose, M. H. M., Keppler, B., Helbich, T. H. & Aszmann, O. C.
Frontiers in Medicine (2020) 7, 613138

Plecstatin-1 induces an immunogenic cell death signature in colorectal tumour spheroids
Wernitznig, D., Meier-Menches, S. M., Cseh, K., Theiner, S., Wenisch, D., Schweikert, A., Jakupec, M. A., Koellensperger, G., Wernitznig, A., Sommergruber, W. & Keppler, B. K.
Metallomics (2020) 12, 12, 2121-2133

Discrimination of Aluminum from Silicon by Electron Crystallography with the JUNGFRAU Detector
Frojdh, E., Wennmacher, J. T. C., Rzepka, P., Mozzanica, A., Redford, S., Schmitt, B., van Bokhoven, J. A. & Gruene, T.
Crystals (2020) 10, 12, 1148

Sensing of Proteins by ICD Response of Iron(II) Clathrochelates Functionalized by Carboxyalkylsulfide Groups
Losytskyy, M., Chornenka, N., Vakarov, S., Meier-Menches, S. M., Gerner, C., Potocki, S., Arion, V. B., Gumienna-Kontecka, E., Voloshin, Y. & Kovalska, V.
Biomolecules (2020) 10, 12, 1602

Introducing N-, P-, and S-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes
Harringer, S., Wernitznig, D., Gajic, N., Diridl, A., Wenisch, D., Hejl, M., Jakupec, M. A., Theiner, S., Koellensperger, G., Kandioller, W. & Keppler, B. K.
Dalton Transactions (2020) 49, 44, 15693-15711

Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect
Legin, A., Schintlmeister, A., Sommerfeld, N., Eckhard, M., Theiner, S., Reipert, S., Strohhofer, D., Jakupec, M., Galanski, M., Wagner, M. & Keppler, B.
Nanoscale Advances (2020) 3, 1, 249-262

Synthetically Versatile Nitrogen Acyclic Carbene Stabilized Gold Nanoparticles
Rubio, G. M. D. M., Keppler, B. K., Chin, J. M. & Reithofer, M. R.
Chemistry: A European Journal (2020)

First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations
Harringer, S., Matzinger, M., Gajic, N., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Inorganica Chimica Acta (2020) 513, 119919

Low cost DNA data storage using photolithographic synthesis and advanced information reconstruction and error correction
Antkowiak, P. L., Lietard, J., Darestani, M. Z., Somoza, M. M., Stark, W. J., Heckel, R. & Grass, R. N.
Nature Communications (2020) 11, 1, 5345

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs
Mathuber, M., Schueffl, H., Dömötör, O., Karnthaler, C., Enyedy, É. A., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Inorganic Chemistry (2020)

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation
Enyedy, É. A., May, N. V., Pape, V. F. S., Heffeter, P., Szakács, G., Keppler, B. K. & Kowol, C. R.
Dalton Transactions (2020)

An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
Meier-Menches, S. M., Neuditschko, B., Zappe, K., Schaier, M., Gerner, M. C., Schmetterer, K. G., Del Favero, G., Bonsignore, R., Cichna-Markl, M., Koellensperger, G., Casini, A. & Gerner, C.
Chemistry: A European Journal (2020) 26, 67, 15528 –15537

Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting
Lahnsteiner, M., Kastner, A., Mayr, J., Roller, A., Keppler, B. K. & Kowol, C. R.
Chemistry: A European Journal (2020)

Straightforward chemoselective access to unsymmetrical dithioacetals through a thiosulfonate homologation-nucleophilic substitution sequence
Ielo, L., Pillari, V., Gajic, N., Holzer, W. & Pace, V.
Chemical Communications (2020) 56, 82, 12395-12398

Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers
Ozenil, M., Pacher, K., Balber, T., Vraka, C., Roller, A., Holzer, W., Spreitzer, H., Mitterhauser, M., Wadsak, W., Hacker, M. & Pichler, V.
European Journal of Medicinal Chemistry (2020) 204, 112623

l-DNA Duplex Formation as a Bioorthogonal Information Channel in Nucleic Acid-Based Surface Patterning
Schaudy, E., Somoza, M. M. & Lietard, J.
Chemistry: A European Journal (2020) 26, 63, 14310-14314

Ameliorative effects of deferiprone and tetraethylammonium salt of salinomycinic acid on lead-induced toxicity in mouse testes
Pavlova, E., Pashkunova-Martic, I., Schaier, M., Petrova, E., Gluhcheva, Y., Dorkov, P., Helbich, T. H., Keppler, B., Koellensperger, G. & Ivanova, J.
Environmental Science and Pollution Research (2020)

C,N-chelated diaminocarbene platinum(II) complexes derived from 3,4-diaryl-1H-pyrrol-2,5-diimines and cis-dichlorobis(isonitrile) platinum(II): Synthesis, cytotoxicity, and catalytic activity in hydrosilylation reactions
Afanasenko, A. M., Chulkova, T. G., Boyarskaya, I. A., Islamova, R. M., Legin, A. A., Keppler, B. K., Selivanov, S., Vereshchagin, A. N., Elinson, M. N. & Haukka, M.
Journal of Organometallic Chemistry (2020) 923, 121435

Halogen-Imparted Reactivity in Lithium Carbenoid Mediated Homologations of Imine Surrogates: Direct Assembly of bis-Trifluoromethyl-beta-Diketiminates and the Dual Role of LiCH2I
Ielo, L., Castoldi, L., Touqeer, S., Lombino, J., Roller, A., Prandi, C., Holzer, W. & Pace, V.
Angewandte Chemie (International Edition) (2020), 132, 47

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters
Milunovic, M. N. M., Palamarciuc, O., Sirbu, A., Shova, S., Dumitrescu, D., Dvoranova, D., Rapta, P., Petrasheuskaya, T. V., Enyedy, E. A., Spengler, G., Ilic, M., Sitte, H. H., Lubec, G. & Arion, V. B.
Biomolecules (2020) 10, 9, 1213

Melanoidins from coffee and bread differently influence energy intake: A randomized controlled trial of food intake and gut-brain axis response
Walker, J. M., Mennella, I., Ferracane, R., Tagliamonte, S., Holik, A-K., Hoelz, K., Somoza, M. M., Somoza, V., Fogliano, V. & Vitaglione, P.
Journal of Functional Foods (2020) 72, 104063

Synthesis, characterization, antimicrobial and cytotoxic activity of novel half-sandwich Ru(II) arene complexes with benzoylthiourea derivatives
Obradovic, D., Nikolic, S., Milenkovic, I., Milenkovic, M., Jovanovic, P., Savic, V., Roller, A., Crnogorac, M. D., Stanojkovic, T. & Grguric-Sipka, S.
Journal of Inorganic Biochemistry (2020) 210, 111164

Triapine derivatives act as copper delivery vehicles to induce deadly metal overload in cancer cells
Ohui, K., Stepanenko, I., Besleaga, I., Babak, M. V., Stafi, R., Darvasiova, D., Giester, G., Pósa, V., Enyedy, E. A., Vegh, D., Rapta, P., Ang, W. H., Popović-Bijelić, A. & Arion, V. B.
Biomolecules (2020) 10, 9, S. 1-22 1336

Formation of metal-radical species upon reduction of late transition metal complexes with heteroleptic ligands: an experimental and theoretical study
Malček, M., Kožíšková, J., Herich, P., Rapta, P., Stepanenko, I. & Arion, V. B.
New Journal of Chemistry (2020) 44, 30, 13195-13206

Nickel(II), Copper(II) and Palladium(II) Complexes with Bis-Semicarbazide Hexaazamacrocycles: Redox-Noninnocent Behavior and Catalytic Activity in Oxidation and C-C Coupling Reactions
Dobrov, A., Fesenko, A., Yankov, A., Stepanenko, I., Darvasiova, D., Breza, M., Rapta, P., Martins, L. M. D. R. S., Pombeiro, A. J. L., Shutalev, A. & Arion, V. B.
Inorganic Chemistry (2020) 59, 15, 10650-10664

Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy
Theiner, S., Schweikert, A., Haberler, C., Peyrl, A. & Koellensperger, G.
Metallomics (2020) 12, 8, 1246-1252

1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity
Recnik, L-M., Kandioller, W. & Mindt, T. L.
Molecules (2020) 25, 16, 3576

I-124 Radiolabeling of a Au-III-NHC Complex for In Vivo Biodistribution Studies
Guarra, F., Terenzi, A., Pirker, C., Passannante, R., Baier, D., Zangrando, E., Gomez-Vallejo, V., Biver, T., Gabbiani, C., Berger, W., Llop, J. & Salassa, L.
Angewandte Chemie (International Edition) (2020) 132, 39, 17278-17284

Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity
Vrettos, E., Valverde, I. E., Mascarin, A., Pallier, P. N., Cerofolini, L., Fragai, M., Parigi, G., Hirmiz, B., Bekas, N., Grob, N. M., Shaye, H., Del Borgo, M., Aguilar, M., Magnani, F., Syed, N., Crook, T., Waqif, E., Ghazaly, E., Cherezov, V., Widdop, R. E., Luchinat, C., Michael-Titus, A. T., Mindt, T. L., Tzakos, A. G. & Stylos, E. K.
Chemistry: A European Journal (2020) 26, 47, 10690-10694

Radiolabelling of the octadentate chelators DFO* and oxoDFO* with zirconium-89 and gallium-68
Brandt, M., Cowell, J., Aulsebrook, M. L., Gasser, G. & Mindt, T. L.
Journal of Biological Inorganic Chemistry (2020) 25, 789–796

Aluminum in Coffee
Windisch, J., Keppler, B. K. & Jirsa, F.
ACS Omega (2020) 5, 25, 15335-15343

Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of 99mTc-Tricarbonyl-Based Radiopharmaceuticals
Giammei, C., Balber, T., Benčurová, K., Cardinale, J., Berroterán-Infante, N., Brandt, M., Jouini, N., Hacker, M., Mitterhauser, M. & Mindt, T. L.
Molecules (2020) 25, 11, 2680

Cancer Cell Resistance against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux
Bormio Nunes, J. H., Hager, S., Mathuber, M., Pósa, V., Roller, A., Enyedy, É. A., Stefanelli, A., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Journal of Medicinal Chemistry (2020) 63, 22, 13719-13732

Selective liquid phase micro-extraction of metal chloro-complexes from saline waters using ionic liquids
Herce-Sesa, B., Pirkwieser, P., Lopez-Lopez, J. A., Jirsa, F. & Moreno, C.
Journal of cleaner production (2020) 262, 121415

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones
Hager, S., Pape, V. F. S., Posa, V., Montsch, B., Uhlik, L., Szakacs, G., Toth, S., Jabronka, N., Keppler, B. K., Kowol, C. R., Enyedy, E. A. & Heffeter, P.
Antioxidants and Redox Signaling (2020), 395-414

How versatile is the use of ultrafiltration to study biointeractions of therapeutic metallodrugs?
Foteeva, L. S., Kuznetsova, O. & Keppler, B. K.
Analytical Biochemistry (2020) 598, 113697

Cation-Directed Synthetic Strategy Using 4f Tungstoantimonates as Nonlacunary Precursors for the Generation of 3d-4f Clusters
Tanuhadi, E., Al-Sayed, E., Novitchi, G., Roller, A., Giester, G. & Rompel, A.
Inorganic Chemistry (2020) 59, 12, 8461-8467

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib
Bielec, B., Schueffl, H., Terenzi, A., Berger, W., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Bioorganic Chemistry (2020) 99, 103778

Diversity of digenean trematode larvae in snails from Lake Victoria, Kenya: First reports and bioindicative aspects
Outa, J. O., Sattmann, H., Koehsler, M., Walochnik, J. & Jirsa, F.
Acta Tropica (2020) 206, 105437

Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions
Grob, N. M., Schmid, S., Schibli, R., Behe, M. & Mindt, T. L.
Journal of Medicinal Chemistry (2020) 63, 9, 4496-4505

Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting
Grob, N. M., Haussinger, D., Deupi, X., Schibli, R., Behe, M. & Mindt, T. L.
Medicinal Chemistry (2020) 63, 9, 4484-4495

Fast and Highly Efficient Affinity Enrichment of Azide-A-DSBSO Cross-Linked Peptides
Matzinger, M., Kandioller, W., Doppler, P., Heiss, E. H. & Mechtler, K.
Journal of Proteome Research (2020) 19, 5, 2071-2079

Heavy Metal Extraction under Environmentally Relevant Conditions Using 3-Hydroxy-2-Naphthoate- Based Ionic Liquids: Extraction Capabilities vs. Acute Algal Toxicity
Pirkwieser, P., López-López, J. A., Schagerl, M., Kandioller, W., Keppler, B. K., Moreno, C. & Jirsa, F.
Applied Sciences (2020)10, 9, 3157

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior
Harringer, S., Happl, B., Ozenil, M., Kast, C., Hejl, M., Wernitznig, D., Legin, A. A., Schweikert, A., Gajic, N., Roller, A., Koellensperger, G., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2020) 26, 24, 5419-5433

Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin
Bijelic, A., Dobrov, A., Roller, A. & Rompel, A.
Inorganic Chemistry (2020) 59, 8, 5243-5246

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles
Mokesch, S., Cseh, K., Geisler, H., Hejl, M., Klose, M. H. M., Roller, A., Meier-Menches, S. M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Frontiers in Chemistry (2020) 8, 209

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., Gurnhofer, E., Schlederer, M., Limberger, T., Lagger, S., Pencik, J., Kodajova, P., Hoegler, S., Stockmaier, G., Grund-Groeschke, S., Aberger, F., Bolis, M., Theurillat, J-P., Wiebringhaus, R., Weiss, T., Haitel, A., Brehme, M., Wadsak, W., Griss, J., Mohr, T., Hofer, A., Jaeger, A., Pollheimer, J., Egger, G., Koellensperger, G., Mann, M., Hantusch, B. & Kenner, L.
Molecular Systems Biology (2020) 16, 4, 9247

Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization
Zhang, H., Riomet, M., Roller, A. & Maulide, N.
Organic Letters (2020) 22, 6, 2376-2380

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase II alpha inhibitors
Legina, M. S., Nogueira, J. J., Kandioller, W., Jakupec, M. A., Gonzalez, L. & Keppler, B. K.
Journal of Biological Inorganic Chemistry (2020), 451-465

Bitter-Tasting Amino Acids L-Arginine and L-Isoleucine Differentially Regulate Proton Secretion via T2R1 Signaling in Human Parietal Cells in Culture
Stoeger, V., Holik, A-K., Hoelz, K., Dingjan, T., Hans, J., Ley, J. P., Krammer, G. E., Niv, M. Y., Somoza, M. M. & Somoza, V.
Journal of Agricultural and Food Chemistry (2020) 68, 11, 3434-3444

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib
Englinger, B., Laemmerer, A., Moser, P., Kallus, S., Roehrl, C., Pirker, C., Baier, D., Mohr, T., Niederstaetter, L., Meier-Menches, S. M., Gerner, C., Gabler, L., Gojo, J., Timelthaler, G., Senkiv, J., Jaeger, W., Kowol, C. R., Heffeter, P. & Berger, W.
International Journal of Cancer (2020)

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb-III}(4)(A-alpha-XW9O34)(2)](n-) (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity
Ma, T., Yang, P., Dammann, I., Lin, Z., Mougharbel, A. S., Li, M-X., Adasalitei, F., Mitea, R., Silvestru, C., Thorstenson, C., Ullrich, M. S., Cseh, K., Jakupec, M. A., Keppler, B. K., Donalisio, M., Cavalli, R., Lembo, D. & Kortz, U.
Inorganic Chemistry (2020) 59, 2978-2987

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib
Bielec, B., Poetsch, I., Ahmed, E., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Molecules (2020) 25, 5

The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
Neuditschko, B., Janker, L., Niederstaetter, L., Brunmair, J., Krivanek, K., Izraely, S., Sagi-Assif, O., Meshel, T., Keppler, B. K., Del Favero, G., Witz, I. P. & Gerner, C.
Molecular and Cellular Proteomics (2020) 19, 3, 478-489

Incorporation of Cr-III into a Keggin Polyoxometalate as a Chemical Strategy to Stabilize a Labile {(CrO4)-O-III}Tetrahedral Conformation and Promote Unattended Single-Ion Magnet Properties
Gumerova, N. I., Roller, A., Giester, G., Krzystek, J., Cano, J. & Rompel, A.
Journal of the American Chemical Society (2020) 142, 7, 3336-3339

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behavior
Geisler, H., Wernitznig, D., Hejl, M., Gajic, N., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (2020) 49, 5, 1393-1397

A Many-Faced Alkaloid: Polymorphism of (-)-Monophyllidin
Dank, C., Wurzer, R., Felsinger, S., Bugl, R., Kaehlig, H., Hela, W., Roller, A. & Gstach, H.
Molecules (2020) 25, 3, 449

Synthesis and antiproliferative activity of benzimidazole-based, trinuclear neutral cyclometallated and cationic-chelated ruthenium(II) complexes
Welsh, A., Rylands, L., Arion, V. B., Prince, S. & Smith, G. S.
Dalton Transactions (2020) 49, 4, 1143-1156

Distribution of arsenic, silver, cadmium, lead and other trace elements in water, sediment and macrophytes in the Kenyan part of Lake Victoria: spatial, temporal and bioindicative aspects
Outa, J. O., Kowenje, C. O., Plessl, C. & Jirsa, F., Jan
Environmental Science and Pollution Research (2020) 27, 2, 1485-1498

Heterogeneity of nano-sized zeolite crystals
Wennmacher, J. T. C., Li, T., Zaubitzer, C., Gemmi, M., Mugnaioli, E., Gruene, T. & van Bokhoven, J.
Microporous and Mesoporous Materials (2020) 294, 109897

Trace Elements in Crustaceans, Mollusks and Fish in the Kenyan Part of Lake Victoria: Bioaccumulation, Bioindication and Health Risk Analysis
Outa, J. O., Kowenje, C. O., Avenant-Oldewage, A. & Jirsa, F.
Archives of Environmental Contamination and Toxicology (2020)

Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
Meszaros, J. P., Geisler, H., Poljarevic, J. M., Roller, A., Legina, M. S., Hejl, M., Jakupec, M. A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
Journal of Organometallic Chemistry (2020) 907, 121070

Facile synthesis of 1-butylamino- and 1,4-bis(butylamino)-2-alkyl-9,10-anthraquinone dyes for improved supercritical carbon dioxide dyeing
Jaxel, J., Amer, H., Bacher, M., Roller, A., Guggenberger, M., Zwirchmayr, N. S., Hansmann, C. & Liebner, F.
Dyes and Pigments (2020) 173, 107991

Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters
Kalaba, P., Ilić, M., Aher, N. Y., Dragačević, V., Wieder, M., Zehl, M., Wackerlig, J., Beyl, S., Sartori, S. B., Ebner, K., Roller, A., Lukic, N., Beryozkina, T., Gonzalez, E. R. P., Neill, P., Khan, J. A., Bakulev, V., Leban, J. J., Hering, S., Pifl, C., Singewald, N., Lubec, J., Urban, E., Sitte, H. H., Langer, T. & Lubec, G.
Journal of Medicinal Chemistry (2020) 63, 1, 391-417