Publications 2021


  • Bioinorganic Chemistry

Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics
Riedl, C. A., Rosner, A., Harringer, S., Salomon, P., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Journal of Inorganic Biochemistry (2021), 225, 111618

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
Terenzi, A., La Franca, M., van Schoonhoven, S., Panchuk, R., Martinez, A., Heffeter, P., Gober, R., Pirker, C., Vician, P., Kowol, C. R., Stoika, R., Salassa, L., Rohr, J. & Berger, W.
Communications Chemistry (2021) 4, 1, 162

Crystal structure of trans-diaqua(1,4,8,11-tetraazaundecane)nickel(II) bis(pyridine-2,6-dicarboxylato)nickel(II)
Andriichuk, I. L., Tsymbal, L., Arion, V. B. & Lampeka, Y. D.
Acta Crystallographica Section E: Crystallographic Communications (2021) 77, 1175-1179

Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal
Jarosz, M., Keppler, B. K. & Timerbaev, A. R.
Analytical and Bioanalytical Chemistry (2021)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
Kater, L., Kater, B., Jakupec, M. A., Keppler, B. K. & Prokop, A.
Journal of Biological Inorganic Chemistry (2021) 26, 897-907

Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes
Mathuber, M., Hager, S., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Dalton Transactions (2021) 50, 16053-16066

Wells-Dawson phosphotungstates as mushroom tyrosinase inhibitors: a speciation study
Lampl, R., Breibeck, J., Gumerova, N., Galanski, M. S. & Rompel, A.
Scientific Reports (2021) 11, 1, 19354

Catalytically Active Gold Nanomaterials Stabilized by N-heterocyclic Carbenes
Eisen, C., Chin, J. M. & Reithofer, M. R.
Chemistry: An Asian Journal (2021) 20, 16, 3026-3037

Finger sweat analysis enables short interval metabolic biomonitoring in humans
Brunmair, J., Gotsmy, M., Niederstaetter, L., Neuditschko, B., Bileck, A., Slany, A., Feuerstein, M. L., Langbauer, C., Janker, L., Zanghellini, J., Meier-Menches, S. M. & Gerner, C.
Nature Communications (2021) 12, 1, 5993

Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression
Kiakos, K., Satam, V., Patil, P. C., Sweers, J., Bowerman, M., Tzou, S., Olsen, K., Lee, M., Schaschl, H., Keppler, B. K., Hochhauser, D., Lee, M., Hartley, J. A. & Pett, L.
Bioorganic & Medicinal Chemistry Letters (2021) 47, 128158

Evaporation-Induced Self-Assembly of Small Peptide-Conjugated Silica Nanoparticles
von Baeckmann, C., Rubio, G. M. D. M., Kaehlig, H., Kurzbach, D., Reithofer, M. R. & Kleitz, F.
Angewandte Chemie (International Edition) (2021) 60, 42, 22700-22705

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo
Schueffl, H., Theiner, S., Hermann, G., Mayr, J., Fronik, P., Groza, D., van Schonhooven, S., Galvez, L., Sommerfeld, N. S., Schintlmeister, A., Reipert, S., Wagner, M., Mader, R. M., Koellensperger, G., Keppler, B. K., Berger, W., Kowol, C. R., Legin, A. & Heffeter, P.
Chemical Science (2021) 38, 12587-12599

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Fronik, P., Poetsch, I., Kastner, A., Mendrina, T., Hager, S., Hohenwallner, K., Schueffl, H., Herndler-Brandstetter, D., Koellensperger, G., Rampler, E., Kopecka, J., Riganti, C., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Journal of Medicinal Chemistry (2021) 64, 16, 12132-12151

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels
Neuditschko, B., Leibetseder, M., Brunmair, J., Hagn, G., Skos, L., Gerner, M. C., Meier-Menches, S. M., Yotova, I. & Gerner, C.
Biomolecules (2021) 11, 8, 1230

Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids
Petrasheuskaya, T. V., Wernitznig, D., Kiss, M. A., May, N. V., Wenisch, D., Keppler, B. K., Frank, E. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2021) 26, 775-791

Hunting for bis-bibenzyls in Primula veris subsp. macrocalyx (Bunge) Lüdi: Organ-specific accumulation and cytotoxic activity
Bukvicki, D., Kovtonyuk, N. K., Legin, A. A., Keppler, B. K., Brecker, L., Asakawa, Y. & Vetschera, K.
Phytochemistry Letters (2021) 44, 90-97

Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer
Herrmann, H. A., Rusz, M., Baier, D., Jakupec, M. A., Keppler, B. K., Berger, W., Koellensperger, G. & Zanghellini, J.
Cancers (2021) 13, 16, 4130

Towards understanding the magnetism of Os(iv) complexes: an ab initio insight
Ungur, L., Pallitsch, K., AlOthman, Z. A., Al-Kahtani, A. A. S., Arion, V. B. & Chibotaru, L. F.
Dalton Transactions (2021), 50, 12537-12546

Morpho-metabotyping the oxidative stress response
Rusz, M., Del Favero, G., El Abiead, Y., Gerner, C., Keppler, B. K., Jakupec, M. A. & Koellensperger, G.
Scientific Reports (2021) 11, 1, 15471

Toward a deeper and simpler understanding of serum protein-mediated transformations of magnetic nanoparticles by ICP-MS
Kuznetsova, O., Jarosz, M., Keppler, B. K. & Timerbaev, A. R.
Talanta (2021) 229, 122287

Ni Oxidation State and Ligand Saturation Impact on the Capability of Octaazamacrocyclic Complexes to Bind and Reduce CO2
Venosova, B., Jelemenska, I., Kozisek, J., Rapta, P., Zalibera, M., Novotny, M., Arion, V. B. & Bucinsky, L.
Molecules (2021) 26, 14, 4139

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
Geisler, H., Westermayr, J., Cseh, K., Wenisch, D., Fuchs, V., Harringer, S., Plutzar, S., Gajic, N., Hejl, M., Jakupec, M. A., Marquetand, P. & Kandioller, W.
Inorganic Chemistry (2021) 60, 13, 9805-9819

Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition
Besleaga, I., Stepanenko, I., Petrasheuskaya, T., Darvasiova, D., Breza, M., Hammerstad, M., Marc, M. A., Prado-Roller, A., Spengler, G., Popovic-Bijelic, A., Enyedy, E. A., Rapta, P., Shutalev, A. D. & Arion, V. B.
Inorganic Chemistry (2021) 60, 15, 11297-11319

Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity
Enyedy, E. A., Petrasheuskaya, T., Kiss, M. A., Wernitznig, D., Wenisch, D., Keppler, B. K., Spengler, G., May, N., Frank, E. & Domotor, O.
Journal of Inorganic Biochemistry (2021) 220, 111468

Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity
Stepanenko, I., Babak, M. V., Spengler, G., Hammerstad, M., Popovic-Bijelic, A., Shova, S., Buchel, G. E., Darvasiova, D., Rapta, P. & Arion, V. B.
Biomolecules (2021) 11, 6, 862

Multifunctional Pt(iv) prodrug candidates featuring the carboplatin core and deferoxamine
Harringer, S., Hejl, M., Enyedy, E. A., Jakupec, M. A., Galanski, M. S., Keppler, B. K., Dyson, P. J. & Varbanov, H. P.
Dalton Transactions (2021) 50, 8167-8178

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS
Schweikert, A., Theiner, S., Wernitznig, D., Schoeberl, A., Schaier, M., Neumayer, S., Keppler, B. K. & Koellensperger, G.
Analytical and Bioanalytical Chemistry (2021)

Current trends and challenges in analysis and characterization of engineered nanoparticles in seawater
Timerbaev, A. R., Kuznetsova, O. & Keppler, B. K.
Talanta (2021) 226, 122201

Red Blood Cell Stiffness and Adhesion Are Species-Specific Properties Strongly Affected by Temperature and Medium Changes in Single Cell Force Spectroscopy
Baier, D., Mueller, T., Mohr, T. & Windberger, U.
Molecules (2021) 26, 9, 2771

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function
Del Favero, G., Janker, L., Neuditschko, B., Hohenbichler, J., Kiss, E., Woelflingseder, L., Gerner, C. & Marko, D.
Archives of Toxicology (2021) 95, 2201–2221

Coordination Polymers of the Macrocyclic Nickel(II) and Copper(II) Complexes with Isomeric Benzenedicarboxylates: The Case of Spatial Complementarity between the Bis-Macrocyclic Complexes and o-Phthalate
Tsymbal, L., Andriichuk, I. L., Shova, S., Trzybinski, D., Wozniak, K., Arion, V. B. & Lampeka, Y. D.
Crystal Growth & Design (2021) 21, 4, 2355-2370

Mass spectrometry techniques for imaging and detection of metallodrugs
Theiner, S., Schoeberl, A., Schweikert, A., Keppler, B. K. & Koellensperger, G.
Current opinion in chemical biology (2021) 61, 123-134

Development of a cobalt(iii)-based ponatinib prodrug system
Mathuber, M., Gutmann, M., La Franca, M., Vician, P., Laemmerer, A., Moser, P., Keppler, B. K., Berger, W. & Kowol, C. R.
Inorganic Chemistry Frontiers (2021)

Doubly derivatized poly(lactide)-albumin nanoparticles as blood vessel-targeted transport device for magnetic resonance imaging (MRI)
Pashkunova-Martic, I., Kremser, C., Talasz, H., Mistlberger, K., Bechter-Hugl, B., Pfaller, K., Baurecht, D., Debbage, P., Jaschke, W., Helbich, T. H. & Keppler, B.
Journal of Nanoparticle Research (2021) 23, 2, 51

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum
Neuditschko, B., Legin, A. A., Baier, D., Schintlmeister, A., Reipert, S., Wagner, M., Keppler, B. K., Berger, W., Meier-Menches, S. M. & Gerner, C.
Angewandte Chemie (International Edition) (2021) 60, 10, 5063-5068

Highly Aromatic Flavan-3-ol Derivatives from Palaeotropical Artocarpus lacucha Buch.-Ham Possess Radical Scavenging and Antiproliferative Properties
Songoen, W., Phanchai, W., Brecker, L., Wenisch, D., Jakupec, M. A., Pluempanupat, W. & Schinnerl, J.
Molecules (2021) 26, 4, 1078

Recurrent Topics in Mass Spectrometry-Based Metabolomics and Lipidomics-Standardization, Coverage, and Throughput
Rampler, E., El Abiead, Y., Schoeny, H., Rusz, M., Hildebrand, F., Fitz, V. & Koellensperger, G.
Analytical Chemistry (2021) 93, 1, 519-545

Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture
Niederstaetter, L., Neuditschko, B., Brunmair, J., Janker, L., Bileck, A., Del Favero, G. & Gerner, C.
Biomolecules (2021) 11, 1, 113

Spectroelectrochemical Properties and Catalytic Activity in Cyclohexane Oxidation of the Hybrid Zr/Hf-Phthalocyaninate-Capped Nickel(II) and Iron(II) tris-Pyridineoximates and Their Precursors
Voloshin, Y. Z., Dudkin, S. V., Belova, S. A., Gherca, D., Samohvalov, D., Manta, C-M., Lungan, M-A., Meier-Menches, S. M., Rapta, P., Darvasiova, D., Malcek, M., Pombeiro, A. J. L., Martins, L. M. D. R. S. & Arion, V. B.
Molecules (2021) 26, 2, 336

  • Bioinorganic Radiochemistry

The Race for Hydroxamate-Based Zirconium-89 Chelators
Feiner, I. V. J., Brandt, M., Cowell, J., Demuth, T., Vugts, D., Gasser, G. & Mindt, T. L.
Cancers (2021) 13, 17, 4466

Development and in vitro evaluation of new bifunctional Zr-89-chelators based on the 6-amino-1,4-diazepane scaffold for immuno-PET applications
Klasen, B., Lemcke, D., Mindt, T. L., Gasser, G. & Roesch, F.
Nuclear Medicine and Biology (2021), 102, 12-23

Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin Lu-177-PP-F11N
Grob, N. M., Schibli, R., Behe, M. & Mindt, T. L.
Cancers (2021) 13, 11, 2629

1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs
Grob, N. M., Schibli, R., Behe, M., Valverde, I. E. & Mindt, T. L.
ACS Medicinal Chemistry Letters (2021) 12, 4, 585-592

Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis
McLaughlin, M., Pallitsch, K., Wallner, G., van der Donk, W. A. & Hammerschmidt, F.
Biochemistry (2021) 60, 20, 1587-1596

Determination of Characteristic vs Anomalous Cs-135/Cs-137 Isotopic Ratios in Radioactively Contaminated Environmental Samples
Zok, D., Blenke, T., Reinhard, S., Sprott, S., Kegler, F., Syrbe, L., Querfeld, R., Takagai, Y., Drozdov, V., Chyzhevskyi, I., Kirieiev, S., Schmidt, B., Adlassnig, W., Wallner, G., Dubchak, S. & Steinhauser, G.
Environmental Science & Technology (2021) 55, 8, 4984-4991

  • Environmental Chemistry

Ingredient-Dependent Extent of Lipid Oxidation in Margarine
Fruehwirth, S., Egger, S., Kurzbach, D., Windisch, J., Jirsa, F., Flecker, T., Ressler, M., Reiner, A. T., Firat, N. & Pignitter, M.
Antioxidants (2021) 10, 1, 105

Helminths of the mallard Anas platyrhynchos Linnaeus, 1758 from Austria, with emphasis on the morphological variability of Polymorphus minutus Goeze, 1782
Jirsa, F., Reier, S. & Smales, L.
Journal of Helminthology (2021) 95, e16

Parasite diversity of introduced fish Lates niloticus, Oreochromis niloticus and endemic Haplochromis spp. of Lake Victoria, Kenya
Outa, J. O., Dos Santos, Q. M., Avenant-Oldewage, A. & Jirsa, F.
Parasitology Research (2021)

Expression, Purification, and Characterization of a Well-Adapted Tyrosinase from Peatlands Identified by Partial Community Analysis
Panis, F., Krachler, R. F., Krachler, R. & Rompel, A.
Environmental Science & Technology (2021) 55, 16, 11445-11454

Northern High-Latitude Organic Soils as a Vital Source of River-Borne Dissolved Iron to the Ocean
Krachler, R. & Krachler, R. F.
Environmental Science & Technology (2021) 55, 14, 9672-9690

  • Nucleic Acid Chemistry

Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture
Tiroch, J., Sterneder, S., Di Pizio, A., Lieder, B., Hoelz, K., Holik, A. K., Pignitter, M., Behrens, M., Somoza, M., Ley, J. P. & Somoza, V.
Journal of Agricultural and Food Chemistry (2021) 69, 45, 13339-13349

Sequence Preference and Initiator Promiscuity for De Novo DNA Synthesis by Terminal Deoxynucleotidyl Transferase
Schaudy, E., Lietard, J. & Somoza, M. M.
ACS Synthetic Biology (2021) 10, 7, 1750-1760

Sequence Preference and Initiator Promiscuity for De Novo DNA Synthesis by Terminal Deoxynucleotidyl Transferase
Schaudy, E., Lietard, J. & Somoza, M. M.
ACS Synthetic Biology (2021) 10, 7, 1750-1760

Chemical and photochemical error rates in light-directed synthesis of complex DNA libraries
Lietard, J., Leger, A., Erlich, Y., Sadowski, N., Timp, W. & Somoza, M. M.
Nucleic Acids Research (2021) 49, 12, 6687-6701

Gastric Serotonin Biosynthesis and Its Functional Role in L-Arginine-Induced Gastric Proton Secretion
Holik, A-K., Schweiger, K., Stoeger, V., Lieder, B., Reiner, A., Zopun, M., Hoi, J. K., Kretschy, N., Somoza, M. M., Kriwanek, S., Pignitter, M. & Somoza, V.
International Journal of Molecular Sciences (2021) 22, 11, 5881

  • X-ray Structure Analysis Centre

Unexpected scaffold rearrangement product of pirenzepine found in commercial samples
Ozenil, M., Skos, L., Roller, A., Gajic, N., Holzer, W., Spreitzer, H., Platzer-Ozenil, S., Vraka, C., Hacker, M., Wadsak, W. & Pichler, V.
Scientific Reports (2021) 11, 1, 23397

Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues
da Silva, S. R., Kalaba, P., Fabisikova, A., Zehl, M., Dragacevic, V., dos Anjos, L. R., Neill, P. J., Wieder, M., Prado-Roller, A., Gajic, N., Palaretti, V., Jose da Silva, G. V., Pifl, C., Lubec, G. & Perez Gonzalez, E. R.
Amino Acids (2021)

Speciation of Transition-Metal-Substituted Keggin-Type Silicotungstates Affected by the Co-crystallization Conditions with Proteinase K
Breibeck, J., Tanuhadi, E., Gumerova, N. I., Giester, G., Prado-Roller, A. & Rompel, A.
Inorganic Chemistry (2021) 60, 20, 15096−15100

3D Electron Diffraction for Chemical Analysis: Instrumentation Developments and Innovative Applications
Gruene, T. & Mugnaioli, E.
Chemical Reviews (2021) 121, 19, 11823-11834

The Smallest Polyoxotungstate Retained by TRIS-Stabilization
Gumerova, N., Prado-Roller, A., Rambaran, M. A., Ohlin, C. A. & Rompel, A.
Inorganic Chemistry (2021) 60, 17, 12671-12675

Crystal structure of copper perchlorophthalocyanine analysed by 3D electron diffraction
Gorelik, T. E., Habermehl, S., Shubin, A. A., Gruene, T., Yoshida, K., Oleynikov, P., Kaiser, U. & Schmidt, M. U.
Acta crystallographica Section B (2021) 77, 662-675

Racemic and Meso Crystal Structures of an Axial-Chiral Spirobi-(dinaphthoazepin)ium Salt: Emergence of an S-4-Symmetric Molecule
Honegger, P., Gajic, N., Prado-Roller, A. & Widhalm, M.
Symmetry (2021) 13, 8, 1365

Crystal engineering with copper and melamine
Bernabe Virseda, I., Siddiqui, S. A., Prado-Roller, A., Eisterer, M. & Shiozawa, H.
RSC Advances (2021) 11, 39, 23943-23947

Establishing electron diffraction in chemical crystallography
Gruene, T., Holstein, J. J., Clever, G. H. & Keppler, B.
Nature reviews chemistry (2021) 5, 660-668

Defect {(WVIO7)WVI4} and Full {(WVIO7)WVI5} Pentagonal Units as Synthons for the Generation of Nanosized Main Group V Heteropolyoxotungstates
Tanuhadi, E., Gumerova, N., Prado-Roller, A., Mautner, A. & Rompel, A.
Inorganic Chemistry (2021) 60, 12, 8917-8923

Endophytic Akanthomyces sp. LN303 from Edelweiss Produces Emestrin and Two New 2-Hydroxy-4 Pyridone Alkaloids
Oberhofer, M., Wackerlig, J., Zehl, M., Buyuk, H., Cao, J., Prado-Roller, A., Urban, E. & Zotchev, S. B.
ACS Omega (2021) 6, 3, 2184-2191

Synthesis and characterization of enantiopure planar-chiral phosphorus-linked diferrocenes
Honegger, P., Roller, A. & Widhalm, M.
Acta Crystallographica. Section C: Structural Chemistry (2021) 77, 3, 152-160

Aluminum-Substituted Keggin Germanotungstate [HARH(2)O)GeW11O39](4-): Synthesis, Characterization, and Antibacterial Activity
Tanuhadi, E., Gumerova, N., Prado-Roller, A., Galanski, M., Cipcic-Paljetak, H., Verbanac, D. & Rompel, A.
Inorganic Chemistry (2021) 60, 1, 28-31