New insights into the chemistry of the antineoplastic lanthanum complex tris(1,10-phenanthroline)tris(thiocyanato-?N)lanthanum(III) (KP772) and its interaction with biomolecules
- Author(s)
- Florian Biba, Michael Größl, Alexander Egger, Alexander Roller, Christian Hartinger, Bernhard Keppler
- Abstract
The lanthanide complex tris(1,10-phenanthroline)tris(thiocyanato-KN) lanthanum(III) [La(phen)3(NCS)3] (KP772) is a promising anticancer drug candidate, capable of overcoming resistance of tumors to established, chemotherapeutics. The compound was characterized by elemental analysis, IR, 1H NMR spectroscopy, TG/DTA measurements, mass spectrometry and X-ray diffraction analysis. The results indicate that KP772 is a neutral, nine-coordinate complex, In addition the behavior in water, important for the application as a chemotherapeutic drug, and the binding to biomolecules was investigated by capillary electrophoresis and ICP-MS
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- European Journal of Inorganic Chemistry
- Volume
- 28
- Pages
- 4282-4287
- No. of pages
- 6
- ISSN
- 1434-1948
- DOI
- https://doi.org/10.1002/ejic.200900038
- Publication date
- 2009
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/026fda1a-090c-4a06-b3b0-753d949a306b