Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
- Author(s)
- Wolfgang Kandioller, Evelyn Balsano, Samuel Matthias Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael Jakupec, Walter Berger, Bernhard Keppler, Christian G. Hartinger
- Abstract
Organometallic Ru-II, Os-II and Rh-III complexes of lapachol induce apoptosis in human tumour cell lines in the low mu M range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Organic Chemistry
- External organisation(s)
- Medizinische Universität Wien, University of Auckland
- Journal
- Chemical Communications
- Volume
- 49
- Pages
- 3348-3350
- No. of pages
- 3
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/c3cc40432c
- Publication date
- 2013
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301207 Pharmaceutical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/04a12e00-103d-407d-8bd7-ee94664a3e72