NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids
- Author(s)
- Wolfgang Wadsak, Barbara Wirl-Sagadin, Markus Mitterhauser, Leonhard-Key Mien, Dagmar E. Ettlinger, Bernhard Keppler, Robert Dudczak, Kurt Kletter
- Abstract
Nucleophilic aromatic substitution is a challenging task in radiochemistry. Therefore, a thorough evaluation and optimisation of this step is needed to provide a satisfactory tool for the routine preparation of [18F] fluorinated aromatic amino acids. Two methods, already proposed elsewhere, were evaluated and improved. The yields for the radiofluorination were increased whereas activity loss during solid phase extraction was observed. Radiochemical yields for the two methods were 92.7‘5.5% (method 1) and 92.1‘12.3% (method 2) for conversion and 11.1‘2.8% (method 1) and 34.8‘0.6% (method 2) for purification, respectively. In total, we demonstrate an optimised method for the preparation of this important class of [18F]fluorinated synthons for PET. Œ 2005 Elsevier Ltd. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Sport and Human Movement Science
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Applied Radiation and Isotopes
- Volume
- 64
- Pages
- 355-359
- No. of pages
- 5
- ISSN
- 0969-8043
- Publication date
- 2006
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/0bc63b7b-2658-434d-a077-9997bb62f20e