Electrospray ionization mass spectrometric study on the coordination behavior of dacarbazine towards transition metal ions
- Author(s)
- Christian Hartinger, Maria Grazia Mendoza Parra Ferri, Alexey Nazarov, Bernhard Keppler
- Abstract
The complexation properties of dacarbazine (dac), being a compound of interest for anticancer research, were studied by comparison of electrospray ionization mass spectra of isolated transition metal complexes and in situ-formed ones. Therefore, FeCl3 was reacted with dacarbazine at a molar ratio of 1:1 while CoCl2, NiCl2 and cis-[RuCl2(dmso)4] were mixed with the ligand at a 1:2 ratio. The obtained dac complexes were isolated by precipitation and characterized by NMR, ESI-MS, IR and elemental analysis. In order to form complexes in situ, reaction mixtures of the metal salts and the Ru complex with dacarbazine were prepared at molar ratios of both 1:1 and 1:2. Comparison of the data for isolated and in situ-prepared complexes revealed that Fe(III) forms slowly but exclusively a complex of the [Fe(dac)2] type (independent of the ratio between the iron salt and dacarbazine) while incubation of the Ru(II) complex cis-[RuCl2(dmso)4] with dacarbazine yields a mixture of [Ru(dac)] and [Ru(dac)2] type complexes. The exchange of dmso ligands by dacarbazine was found to proceed rather slowly. In contrast, the complexation of Ni(II) and Co(II) towards dacarbazine was much faster and the reaction of dacarbazine with CoCl2 delivers only a [Co(dac)]2 type complex, whereas coordination compounds with Ni(II) were identified to be of [Ni(dac)] and [Ni(dac)2] types when being incubated at molar ratios Ni:dac of 1:1 and 1:2, respectively. Π2006 Elsevier Ltd. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- Polyhedron
- Volume
- 25
- Pages
- 1971-1978
- No. of pages
- 8
- ISSN
- 0277-5387
- Publication date
- 2006
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/0bd3448d-768a-4ebf-bb38-0fe18fa0a53c