Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds
- Author(s)
- Antoine Dorcier, Christian Hartinger, Rosario Scopelliti, Richard H. Fish, Bernhard Keppler, Paul J. Dyson
- Abstract
The reactions of arene-metal complexes (arene = p-cymene, benzene or pentamethylcyclopentadienyl, metal = Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(?5-C10H15)RhCl(pta-Me)2]Cl2, [(?6-C10H14)OsCl(pta)2]Cl, and [(?6-C6H6)OsCl2(CH3CN)], are also reported. © 2007 Elsevier Inc. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- École polytechnique fédérale de Lausanne, University of California, Berkeley
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 102
- Pages
- 1066-1076
- No. of pages
- 11
- ISSN
- 0162-0134
- Publication date
- 2008
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/146e4234-0694-469a-8936-93d4cf58bd73