Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study
- Author(s)
- Eva Anna Enyedy, Michael Primik, Christian Kowol, Vladimir Arion, Tamas Kiss, Bernhard Keppler
- Abstract
Stoichiometry and stability of Ga-III, Fe-III, Fe-II complexes of Triapine and five related alpha-N heterocyclic thiosemicarbazones with potential antitumor activity have been determined by pH-potentiometry, UV-vis spectrophotometry, H-1 NMR spectroscopy, and spectrofluorimetry in aqueous solution (with 30% DMSO), together with the characterization of the proton dissociation processes. Additionally, the redox properties of the iron complexes were studied by cyclic voltammetry at various pH values. Formation of high stability bis-ligand complexes was found in all cases, which are predominant at physiological pH with Fe-III/Fe-II, whilst only at the acidic pH range with Ga-III. The results show that among the thiosemicarbazones with various substituents the N-terminal dimethylation does not exert a measurable effect on the redox potential, but has the highest impact on the stability of the complexes as well as the cytotoxicity, especially in the absence of a pyridine-NH2 group in the molecule. In addition the fluorescence properties of the ligands in aqueous solution and their changes caused by Ga-III were studied.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Szeged
- Journal
- Dalton Transactions
- Volume
- 40
- Pages
- 5895-5905
- No. of pages
- 11
- ISSN
- 1477-9226
- Publication date
- 2011
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/14c1d196-847a-4826-9b12-35d32b24e58c