Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
- Author(s)
- Alexia Tialiou, Jia Min Chin, Bernhard K. Keppler, Michael R. Reithofer
- Abstract
Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Functional Materials and Catalysis
- External organisation(s)
- Medizinische Universität Wien, Research Cluster Translational Cancer Therapy Research, Vienna Doctoral School in Chemistry (DoSChem)
- Journal
- Biomedicines
- Volume
- 10
- No. of pages
- 26
- ISSN
- 2227-9059
- DOI
- https://doi.org/10.3390/biomedicines10061417
- Publication date
- 06-2022
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301904 Cancer research, 106002 Biochemistry, 106023 Molecular biology
- Keywords
- ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology, Medicine (miscellaneous)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/165625f1-af57-4b2f-87fd-06d2abcc3d81