Synthesis, structure, protolytic properties, alkylating and cytotoxic activity of novel platinum(II) and palladium(II) complexes with pyrazole-derived ligands

Author(s)
Elzbieta Budzisz, Magdalena Malecka, Bernhard Keppler, Vladimir Arion, Grzegorz Andrijewski, Urszula Krajewska, Marek Rozalski
Abstract

Novel platinum(II) and palladium(II) complexes [PtCl2(HL 1)] (3a), [NH2CH3)2][PtCl 2(L1)] (3b), [PdCl2(HL1)] (4a), [NH2(CH3)2][PdCl2(L1)] (4b) and [PdCl(CH3CN)(L1)] (4c), where HL1 = 4-(2-hydroxybenzoyl)-2-(pyridin-2-yl)-1H-pyrazol-3-ol, have been synthesised as potential anticancer compounds. Protonation constants of the ligand were determined by pH-metric titration (log K1 = 7.74 ± 0.03; log K2 = 2.85 ± 0.05). The solid-state structures of complexes 3b and 4c have been determined by X-ray diffraction, showing sguare-planar coordination geometry of PtII and PdII ions. In addition, the compounds have been characterised by IR, 1H NMR and FAB mass spectrometry. The results of preliminary studies on the cytotoxic activity in vitro against HL-60 and NALM-6 leukaemia cell lines are also reported and the IC50 values compared with those of the metal-free ligand and cisplatin. Cytotoxic evaluation revealed that PtII and Pd II complexes were active in the micromolar concentration range. © Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Organisation(s)
Department of Inorganic Chemistry
External organisation(s)
Medical University of Lodz, University of Lodz
Journal
European Journal of Inorganic Chemistry
Pages
3728-3735
No. of pages
8
ISSN
1434-1948
Publication date
2007
Peer reviewed
Yes
Austrian Fields of Science 2012
104003 Inorganic chemistry
Portal url
https://ucrisportal.univie.ac.at/en/publications/03be7dc0-0885-4d03-aac7-b65fd700c428