CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP
- Author(s)
- Michael Größl, Christian Hartinger, Paul J. Dyson, Bernhard Keppler
- Abstract
Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research. Hydrolysis and DNA binding play an important role for pharmaceutical formulation and for exerting anticancer activity. Herein, for the first time the application of capillary zone electrophoresis-inductively-coupled plasma mass spectrometry (CZE-ICP-MS) for studying the hydrolytic stability and the binding of the ruthenium anticancer drug candidates KP418, KP1019, and RAPTA-C to dGMP is described. RAPTA-C was found to hydrolyze fastest and showed the highest reactivity toward the DNA model compound, whereas KP418 was the most stable compound in both these respects. © 2007 Elsevier Inc. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- École polytechnique fédérale de Lausanne
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 102
- Pages
- 1060-1065
- No. of pages
- 6
- ISSN
- 0162-0134
- DOI
- https://doi.org/10.1016/j.jinorgbio.2007.11.018
- Publication date
- 2008
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/1dbbc535-a546-4dfe-972d-21b12142eba4