Binding of antitumor ruthenium(III) complexes to plasma proteins
- Author(s)
- Luigi Messori, Francisco Gonzales Vilchez, Rosario A. Vilaplana, F Piccioli, Enzo Alessio, Bernhard Keppler
- Abstract
Presently, there is large interest in analysing the interactions in vitro with plasma proteins of some novel antitumor ruthenium(III) complexes that are in preclinical or clinical phase. The joint application of separation and spectroscopic techniques provides valuable information on the nature and the properties of the resulting ruthenium/protein adducts. Recent work carried out in our laboratory points out that, under physiological conditions, some selected ruthenium(III) complexes bind plasma proteins tightly with a marked preference for surface imidazole groups. Representative examples of interactions of antitumor ruthenium(III) complexes with plasma protiens such as albumin and transferrin are given. Notably the antitumor ruthenium(III) complexes considered here bind proteins much tighter than DNA; it is proposed that protein binding of ruthenium(III) complexes will have a large impact on the biodistribution, the pharmacokinetics and the mechanism of action of these experimental drugs.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Florence, Universidad de Sevilla, Università degli Studi di Trieste
- Journal
- Metal-Based Drugs : MBD
- Volume
- 7
- Pages
- 335-342
- No. of pages
- 8
- ISSN
- 0793-0291
- Publication date
- 2000
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/1dcb818a-9a78-4476-abb5-ca47db2ca2e6