Reaction of (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) with 5'-GMP under simulated physiological conditions, a CZE-ESI-MS study

Author(s): Angelika Kueng, Mathea Sophia Galanski, Christian Baumgartner, Bernhard Keppler
Abstract: Capillary zone electrophoresis (CZE) has been applied for studying the binding behavior of the tumor inhibiting complex (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) to the nucleotide 5'-GMP. Diode array UV detection enabled investigation of the time dependent behavior of 5'-GMP coordination under simulated physiological conditions. The binding behavior has shown to be dependent on the NaCl concentration as well as the pH value. For elucidation of the reaction pathway coupling of CZE to a mass spectrometer via an electrospray interface was applied. Contrary to common platinum complexes used in cancer therapy (e.g. cisplatin), the complex investigated forms a very stable monoadduct via intramolecular ligand attack reaction. Œ 2002 Elsevier Science B.V. All rights reserved.
Organisation(s): Department of Inorganic Chemistry
External organisation(s): University of Vienna
Journal: Inorganica Chimica Acta
Volume: 339
Pages: 9-13
No. of pages: 5
ISSN: 0020-1693
DOI: https://doi.org/10.1016/S0020-1693(02)00915-5
Publication date: 2002
Peer reviewed: Yes
Austrian Fields of Science 2012: 1040 Chemistry
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Portal url: https://ucrisportal.univie.ac.at/en/publications/1f9c02d6-4d1c-4a96-aa87-daacec0e9602