Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates
- Author(s)
- Patrick Bippus, Matthias Skocic, Michael Jakupec, Bernhard Keppler, Fabian Mohr
- Abstract
The thiocarbamates 4-RC6H4NHC(S)NR2' (R = H, Cl; R' = Me, Et), 4-ClC6H4NHC(S)NR (NR = 2-pyridylpiperazine) react with cis-[PtCl2(PTA)(2)] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt(SC(NR2')= NC6H4R)(PTA)(2)](+) (R = H, Cl; R' = Me, Et), cis-[Pt{SC (NR) = NC6H4Cl}(PTA)(2)](+) (NR = 2-pyridylpiperazine), which were isolated as their PF6 salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Bergische Universität Wuppertal
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 105
- Pages
- 462-466
- No. of pages
- 5
- ISSN
- 0162-0134
- DOI
- https://doi.org/10.1016/j.jinorgbio.2010.08.010
- Publication date
- 2011
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/271d289e-eaa2-46f9-b363-13dc433d52ce