Rapid, high-yield enzymatic synthesis of n.c.a. 6-[<sup>18</sup>F]fluorodopamine (6-[<sup>18</sup>F]FDA) for in vivo application
- Author(s)
- Karsten Bamminger, Julia Raitanen, Georgios Karanikas, Sazan Rasul, Lukas Nics, Markus Mitterhauser, Wolfgang Wadsak, Marcus Hacker, Verena Pichler, Chrysoula Vraka
- Abstract
6-[18F]Fluorodopamine (6-[18F]FDA) proved valuable as a diagnostic tool for neuroendocrine and rare tumors, such as ganglioneuromas and pheochromocytomas, however, clinical application is still limited. So far, its radiosyntheses were impeded by the formation of side-products, low molar activity, multi-step reactions and the use of challenging precursors. Here, we describe a detailed enzymatic procedure for fast, simple and high yield synthesis of no carrier added 6-[18F]FDA from 6-[18F]FDOPA with high radiochemical yield of ~69 % and >95 % purity as determined by radio-HPLC and -TLC. The product formulation was stable and suitable for in vivo application.
- Organisation(s)
- Department of Pharmaceutical Sciences
- External organisation(s)
- Medizinische Universität Wien, Centre for Biomarker Research in Medicine – CBmed GmbH, Ludwig Boltzmann Intitute Applied Diagnostics
- Journal
- Nuclear Medicine and Biology
- Volume
- 114-115
- Pages
- 189-197
- No. of pages
- 9
- ISSN
- 0969-8051
- DOI
- https://doi.org/10.1016/j.nucmedbio.2022.07.001
- Publication date
- 2022
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104020 Radiochemistry
- Keywords
- ASJC Scopus subject areas
- Molecular Medicine, Radiology Nuclear Medicine and imaging, Cancer Research
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/27c21448-cf30-477e-90af-09715dd5903d