Physicochemical Studies and Anticancer Potency of Ruthenium eta(6)-p-Cyrnene Complexes Containing Antibacterial Quinolones
- Author(s)
- Jakob Kljun, Anna Bytzek, Wolfgang Kandioller, Caroline Bartel, Michael Jakupec, Christian Hartinger, Bernhard Keppler, Iztok Turel
- Abstract
With the aim of exploring the anticancer properties of organometallic compounds with bioactive ligands, Ru-(arene) compounds of the antibacterial quinolones nalidixic acid (2) and cinoxacin (3) were synthesized, and their physicochemical properties were compared to those of chlorido(e-p-cymene) (ofloxacinato-kappa O-2,O) ruthenium (II) (1). All compounds undergo a rapid. ligand exchange reaction from chlorido to aqua species. 2 and 3 are significantly more stable than 1 and undergo minor conversion to an unreactive [(cym)Ru(mu-OH)(3)Ru-(cym)](+) species (cym = eta(6)-p-cymene). In the presence of human serum albumin 1-3 form adducts with this transport protein within 20 min of incubation. With guanosine 5'-monophosphate (5'-GMP; as a simple model for reactions with DNA) very rapid reactions yielding adducts via its N7 atom were observed, sllustrating that DNA is a possible target for this compound class. A moderate capacity of inhibiting tumor cell proliferation in vitro was observed for 1 in CH1 ovarian cancer cells, when as 2 and 3 turned out to be inactive.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Ljubljana
- Journal
- Organometallics
- Volume
- 30
- Pages
- 2506-2512
- No. of pages
- 7
- ISSN
- 0276-7333
- DOI
- https://doi.org/10.1021/om101180c
- Publication date
- 2011
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301305 Medical chemistry, 104015 Organic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/2956599f-1baf-4fa8-9839-cdb825ff15cb