Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis
- Author(s)
- Angelika Kueng, Thomas Pieper, Bernhard Keppler
- Abstract
Ruthenium(III) complexes of the general formula HL[RuCl4L2], with two trans-standing heterocyclic ligands L bound to ruthenium via nitrogen, show remarkable activity in different tumor models. To obtain a deeper insight into the mode of action of this class of anticancer compounds, we investigated the interaction of HIm trans-[RuCl4(im)2] (im, imidazole) and HInd trans-[RuCl4(ind)2] (ind, indazole) with all four nucleoside monophosphates in buffered solution by means of capillary electrophoresis. A preference for GMP- and AMP-coordination was found. A decrease of the pH resulted in a significantly increased amount of bound nucleotide. This feature seems to be interesting with regard to the lower pH values in solid tumors. Π2001 Elsevier Science B.V.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Vienna
- Journal
- Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
- Volume
- 759
- Pages
- 81-89
- No. of pages
- 9
- ISSN
- 1570-0232
- DOI
- https://doi.org/10.1016/S0378-4347(01)00205-5
- Publication date
- 2001
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/2ab24d02-7e88-4d50-b959-432d2f5debf6