Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
- Author(s)
- Andrea Kurzwernhart, Wolfgang Kandioller, Caroline Bartel, Simone Bächler, Robert Trondl, Gerhard Mühlgassner, Michael Jakupec, Vladimir Arion, Doris Marko, Bernhard Keppler, Christian Hartinger
- Abstract
Ru-II(arene)-flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIa and binding covalently to DNA.
- Organisation(s)
- Department of Inorganic Chemistry, Department of Food Chemistry and Toxicology
- Journal
- Chemical Communications
- Volume
- 48
- Pages
- 4839-4841
- No. of pages
- 3
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/c2cc31040f
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106002 Biochemistry, 301305 Medical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/2ac2aa36-987e-4c84-9707-4e68a0796572