Amidoxime platinum(II) complexes
- Author(s)
- Dmitrii S. Bolotin, Marina Ya. Demakova, Anton A. Legin, Vitaliy V. Suslonov, Alexey A. Nazarov, Michael A. Jakupec, Bernhard K. Keppler, Vadim Yu Kukushkin
- Abstract
The reaction of cis-[PtCl
2(Me
2SO)
2] with 1 equiv. of each of the amidoximes RC(NH
2)NOH in neutral media in MeOH results in the formation of complexes cis-[PtCl
2{RC(NH
2)NOH}(Me
2SO)] (5 examples; 83-98% isolated yields). In the presence of 2 equiv. of NaOH in MeOH solution, the reaction of cis-[PtCl
2(Me
2SO)
2] with 1 equiv. of each of the amidoximes RC(NH
2)NOH leads to [Pt{RC(NH)NO}(Me
2SO)
2] (7 examples; 74-95% isolated yields). All new complexes were characterized by C, H, and N elemental analyses, HRESI
+-MS, IR,
1H,
13C{
1H}, and CP-MAS TOSS
13C{
1H} NMR spectroscopies, and additionally by single-crystal XRD (for seven species). The cytotoxic potency of six compounds was determined in the human cancer cell lines CH1/PA-1, A549, SK-BR-3, and SW480. Generally, the second class of complexes containing chelating amidoximato ligands shows much higher cytotoxicity than the non-chelate amidoxime analogs, despite the lack of easily exchangeable chlorido ligands. Especially, the complex [Pt(p-CF
3C
6H
4C(NH)NO)(Me
2SO)
2] displays a remarkable activity in the inherently cisplatin resistant SW480 cell line (0.51 μM vs. 3.3 μM).
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Saint Petersburg State University, Anuchin Research Institute and Museum of Anthropology
- Journal
- New Journal of Chemistry
- Volume
- 41
- Pages
- 6840-6848
- No. of pages
- 9
- ISSN
- 1144-0546
- DOI
- https://doi.org/10.1039/c7nj00982h
- Publication date
- 07-2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301904 Cancer research
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, General Chemistry, Catalysis
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/2b9bbd0f-b279-4e75-82a4-d3b0fbbec89d