Osmium(IV) complexes with 1H- and 2H-indazoles: Tautomer identity versus spectroscopic properties and antiproliferative activity
- Author(s)
- Gabriel Büchel, Iryna Stepanenko, Michaela Hejl, Michael Jakupec, Bernhard Keppler, Petra Heffeter, Walter Berger, Vladimir Arion
- Abstract
A one-pot synthesis of osmium(IV) complexes with two different tautomers of indazole, 1H-indazole and 2H-indazole. namely (H(2)ind)[(OsCl5)-Cl-IV(2H-ind)] (1) and (H(2)ind)[(OsCl5)-Cl-IV(1H-ind)] (2) is reported. Both compounds have been comprehensively characterized by NMR spectroscopy, ESI (electrospray ionization) mass spectrometry, electronic absorption spectroscopy. IR spectroscopy, cyclic voltammetry and tested for antiproliferative activity in vitro in three human cancer cell lines, CH1 (ovarian carcinoma), A549 (non-small cell lung cancer) and SW480 (colon carcinoma), as well as in vivo in a Hep3B SCID mouse xeno-transplantation model. 2H-Indazole tautomer stabilization in 1 has been confirmed by X-ray diffraction.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 113
- Pages
- 47-54
- No. of pages
- 8
- ISSN
- 0162-0134
- DOI
- https://doi.org/10.1016/j.jinorgbio.2012.04.001
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106023 Molecular biology, 204001 Inorganic chemical technology
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/2c8ead86-02ee-4b8b-934e-d2ce3afc3e1c