Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O, N) donor bidentate ligands
- Author(s)
- Orsolya Domotor, Carmen M. Hackl, Krisztina Bali, Alexander Roller, Michaela Hejl, Michael A. Jakupec, Bernhard K. Keppler, Wolfgang Kandioller, Eva A. Enyedy
- Abstract
Complex formation processes of the (O,N) donor ligands 6-methylpicolinic acid (6-Mepic), quinoline-2-carboxylic acid (2-QA) and 3-isoquinolinecarboxylic acid (3-iQA) with the organometallic moiety (η
5-pentamethylcyclopentadienyl)rhodium(III) (RhCp*) were studied in aqueous solution by the combined use of pH-potentiometry,
1H NMR spectroscopy and UV-Vis spectrophotometry. The solid phase structures of the [RhCp*(L)Cl] complexes bearing 6-Mepic and 2-QA were characterized by single-crystal X-ray diffraction analysis. Studies revealed the exclusive formation of mono complexes of the form [RhCp*(L)(H
2O)]
+ (L = deprotonated form of the ligands) and [RhCp*(L)(OH)]. The positively charged aqua species predominate at physiological pH even in the micromolar concentration range. The H
2O/Cl
− co-ligand exchange constants showed that all complexes preferably retain the chlorido ligand at the third coordination site at chloride ion concentrations present in the serum. In addition in vitro cytotoxicity of these [RhCp*(L)Cl] complexes was evaluated in three human cancer cell lines (A549, SW480 and CH1/PA-1) where they showed minor cytotoxic potency.
- Organisation(s)
- Department of Inorganic Chemistry, Core Facility Crystal Structure Analysis
- External organisation(s)
- University of Szeged
- Journal
- Journal of Organometallic Chemistry
- Volume
- 846
- Pages
- 287-295
- No. of pages
- 9
- ISSN
- 0022-328X
- DOI
- https://doi.org/10.1016/j.jorganchem.2017.06.027
- Publication date
- 10-2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104015 Organic chemistry
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, Biochemistry, Inorganic Chemistry, Physical and Theoretical Chemistry, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/413e2ba4-a780-4f7c-9d12-762f9876fb66