Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH)
- Author(s)
- K. Benjamin Garbutcheon-Singh, Mathea Sophia Galanski, Bernhard K. Keppler, Janice R. Aldrich-Wright
- Abstract
We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine)platinum(II)]
2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 ± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane)platinum(II)]
2+ (1.5 ± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]
2+ (0.10 ± 0.06 μM) and cisplatin (0.43 ± 0.06 μM).
- Organisation(s)
- NMR Centre, Department of Inorganic Chemistry
- External organisation(s)
- Western Sydney University
- Journal
- Inorganica Chimica Acta
- Volume
- 441
- Pages
- 152-156
- No. of pages
- 5
- ISSN
- 0020-1693
- DOI
- https://doi.org/10.1016/j.ica.2015.10.048
- Publication date
- 02-2016
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, Inorganic Chemistry, Physical and Theoretical Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/42291421-7fc8-469b-be35-ab5be4906f52