Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin
- Author(s)
- Sanja Grguric-Sipka, Iryna Stepanenko, Jelena M. Lazic, Caroline Bartel, Michael Jakupec, Vladimir Arion, Bernhard Keppler
- Abstract
The light-protected reaction of [(?6-p-cymene)Ru IICl2]2 with 1-(2-hydroxyethyl)piperazine in dry methanol, followed by addition of excess NH4PF6, afforded the complex [(?6-p-cymene)RuII(NH 3)2Cl](PF6) (1) in 47% yield. Attempts to use the same protocol for the synthesis of [(?6-p-cymene)Os II(NH3)2Cl](PF6) led to the isolation of the binuclear triply methoxido-bridged arene-osmium compound [{(?6-p-cymene)Os}2(?-OCH3) 3](PF6) (3). Both compounds were characterised by X-ray crystallography and 1H NMR spectroscopy, and the ruthenium complex also by spectroscopic techniques (IR and UV-vis spectroscopies). The antiproliferative activity of complex 1in vitro was studied in A549 (non-small cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma) cells and compared to that of [(?6-p-cymene)RuII(en)Cl] (PF6) (2). In contrast to the latter compound, 1 is only modestly cytotoxic in all three cell lines (IC50: 293-542 ?M), probably due to the instability of the diammine ruthenium complex in aqueous solution.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Belgrade
- Journal
- Dalton Transactions
- Volume
- 17
- Pages
- 3334-3339
- No. of pages
- 6
- ISSN
- 1477-9226
- DOI
- https://doi.org/10.1039/b822725j
- Publication date
- 2009
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301305 Medical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/42f9cd01-3afe-4758-9d43-107b01b70f13