Recent development of CE-ICP-MS in biospeciation research and analysis: From anticancer drugs to nanoparticles and beyond
- Author(s)
- Magdalena Matczuk, Lena Ruzik, Andrei R. Timerbaev
- Abstract
Capillary electrophoresis (CE) coupled to ICP-MS occupies its rightful place in mainstream biospeciation analysis, where this coupling is certainly much more than a complementary tool to the other separation-based techniques. This brief review critically discusses the current and emerging capabilities of CE-ICP-MS in the simultaneous detection of chemical species of a given element occurring in samples of biological origin, with a particular focus placed on the areas of metal-based drug and nanoparticle research. The most advantageous separation and detection strategies and the method's analytical performance are illustrated with a selection of real-world applications from recent literature. Among the methodological trends, using tandem and single-particle ICP-MS technology steadily moves to the frontline. Further progress in the field would keep step with more reliable, versatile, and robust CE-ICP-MS assays suitable for routine use.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Warsaw University of Technology
- Journal
- TrAC - Trends in Analytical Chemistry
- Volume
- 180
- ISSN
- 0165-9936
- DOI
- https://doi.org/10.1016/j.trac.2024.117967
- Publication date
- 11-2024
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104002 Analytical chemistry
- Keywords
- ASJC Scopus subject areas
- Analytical Chemistry, Spectroscopy
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/51063242-f96f-46b5-ad93-e43456b39393