Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
- Author(s)
- Michael R. Reithofer, Kiat Hwa Chan, Anupama Lakshmanan, Dang Hoang Lam, Archana Mishra, Began Gopalan, Mangesh Joshi, Shu Wang, Charlotte A.E. Hauser
- Abstract
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.
- Organisation(s)
- External organisation(s)
- Agency for Science, Technology and Research A*STAR
- Journal
- Chemical Science
- Volume
- 5
- Pages
- 625-630
- No. of pages
- 6
- ISSN
- 2041-6520
- DOI
- https://doi.org/10.1039/c3sc51930a
- Publication date
- 02-2014
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301904 Cancer research, 304005 Medical biotechnology
- ASJC Scopus subject areas
- General Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/55872557-ac2a-4523-9e8e-cffc8f4c891e