Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety
- Author(s)
- Wolfgang Kandioller, Christian Hartinger, Alexey Nazarov, Johanna Hubinger-Kasser, Roland John, Michael Jakupec, Vladimir Arion, Paul J. Dyson, Bernhard Keppler
- Abstract
Organometallic ruthenium(II)-arene complexes coordinated to maltol-derived ligands were prepared and their anticancer activity against human tumor cell lines was studied. In addition, their hydrolysis behavior and reaction with 5?-GMP was tested and compared to the parent compound chlorido[2-methyl-3-(oxo-?O)-pyran-4(1H)-onato-?O4](?6-p-cymene)ruthenium(II) (Ru-maltol). Improved stability and in vitro anticancer activity at maintained GMP binding capability were observed, in comparison to the Ru-maltol complex.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- École polytechnique fédérale de Lausanne
- Journal
- Journal of Organometallic Chemistry
- Volume
- 694
- Pages
- 922-929
- No. of pages
- 8
- ISSN
- 0022-328X
- DOI
- https://doi.org/10.1016/j.jorganchem.2008.10.016
- Publication date
- 2009
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301305 Medical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/55dba9e6-4836-4ba4-82b6-42a577f958db