Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible

Author(s): Mathea Sophia Galanski, Afshin Yasemi, Susanna Slaby, Michael Jakupec, Vladimir Arion, Monika Rausch, Alexey Nazarov, Bernhard Keppler
Abstract: Oxaliplatin, (trans-R,R-cyclohexane-1,2-diamine)oxalatoplatinum(II), has recently been approved for combination chemotherapy of metastatic colorectal cancer. Oxaliplatin is significantly more active than its trans-S,S isomer and the mixture of both enantiomers. New oxaliplatin analogues, (SP-4-3)-(4-methyl- trans-cyclohexane-1,2-diamine)oxalatoplatinum(II) and (SP-4-3)-(4-ethyl-trans- cyclohexane-1,2-diamine)oxalatoplatinum(II), have been synthesized, and their cytotoxicity has been tested in comparison to oxaliplatin, its corresponding trans-S,S isomer, and the mixture of both enantiomers. In comparison to oxaliplatin, even the trans-R,R/trans-S,S mixture of the 4-methyl and 4-ethyl substituted oxaliplatin analogues have shown an equivalent cytotoxicity in ovarian cancer cells (CH1) and superior antiproliferative properties in colon cancer cells (SW480) in the case of a predominantly equatorial position of the substituent at position 4 of the trans-cyclohexane-1,2-diamine ligand, whereas an axial substitution results in decreased cytotoxic potency. Œ 2004 Elsevier SAS. All rights reserved.
Organisation(s): Department of Inorganic Chemistry
Journal: European Journal of Medicinal Chemistry
Volume: 39
Pages: 707-714
No. of pages: 8
ISSN: 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2004.04.003
Publication date: 2004
Peer reviewed: Yes
Austrian Fields of Science 2012: 104003 Inorganic chemistry
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Portal url: https://ucrisportal.univie.ac.at/en/publications/561c665a-60ad-4577-ba0b-ba77d8141198