Organometallic Ruthenium and Osmium Compounds of Pyridin-2-and-4-ones as Potential Anticancer Agents
- Author(s)
- Wolfgang Kandioller, Muhammad Hanif, Bernhard Keppler, Christian G. Hartinger
- Abstract
Organometallic RuII compounds are among the most widely studied anticancer agents. Functionalizing metal centers with biomolecule-derived ligands has been shown to be a promising strategy to improve the antiproliferative activity of metal-based chemotherapeutics. Herein, the synthesis of a series of novel 3-hydroxypyridin-2-one-derived ligands and their MII(?6-p-cymene) half-sandwich complexes (M=Ru, Os) is described. The compounds were characterized by 1D- and 2D-NMR spectroscopy, and elemental analysis.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- National University of Sciences and Technology, University of Auckland
- Journal
- Chemistry & Biodiversity
- Volume
- 9
- Pages
- 1718-1727
- No. of pages
- 10
- ISSN
- 1612-1872
- DOI
- https://doi.org/10.1002/cbdv.201200005
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 106002 Biochemistry, 106023 Molecular biology
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/58c27e09-a367-41d7-899b-caa4de2828a7