¹⁸⁷Os nuclear resonance scattering to explore hyperfine interactions and lattice dynamics for biological applications

Author(s)

Iryna Stepanenko, Zhishuo Huang, Liviu Ungur, Dimitrios Bessas, Aleksandr Chumakov, Ilya Sergueev, Gabriel E. Büchel, Abdullah A. Al-Kahtani, Liviu F. Chibotaru, Joshua Telser, Vladimir B. Arion

Abstract

Osmium complexes with osmium in different oxidation states (II, III, IV, and VI) have been reported to exhibit antiproliferative activity in cancer cell lines. Herein, we demonstrate unexplored opportunities offered by ¹⁸⁷Os nuclear forward scattering (NFS) and nuclear inelastic scattering (NIS) of synchrotron radiation for characterization of hyperfine interactions and lattice dynamics in a benchmark Os(VI) complex, K₂[OsO₂(OH)₄]. We determined the isomer shift [δ = 3.3(1) millimeters per second] relative to [Os^IVCl₆]²⁻ and quadrupole splitting [ΔE_Q = 12.0(2) millimeters per second] with NFS. We estimated the Lamb-Mössbauer factor [0.80(4)], extracted the density of phonon states, and carried out a thermodynamics characterization using the NIS data combined with first-principles calculations. Overall, we provide evidence that ¹⁸⁷Os nuclear resonance scattering is a reliable technique for the investigation of hyperfine interactions and Os-specific vibrations in osmium(VI) species and is thus applicable for such measurements in osmium complexes of other oxidation states, including those with anticancer activity such as Os(III) and Os(IV).

Organisation(s)

Department of Inorganic Chemistry

External organisation(s)

IST Austria - Institute of Science and Technology, National University of Singapore (NUS), European Synchrotron Radiation Facility ESRF, Deutsches Elektronen-Synchrotron DESY, ChemConsult GmbH, King Saud University, Katholieke Universiteit Leuven, Roosevelt University

Journal

Science Advances

Volume

11

ISSN

2375-2548

DOI

https://doi.org/10.1126/sciadv.ads3406

Publication date

02-2025

Peer reviewed

Yes

Austrian Fields of Science 2012

104003 Inorganic chemistry, 104020 Radiochemistry, 103006 Chemical physics

ASJC Scopus subject areas

General

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Portal url

https://ucrisportal.univie.ac.at/en/publications/5c3a807f-3e38-47be-a7ce-073259cb6a96