Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex
- Author(s)
- Rosana Hudej, Jakob Kljun, Wolfgang Kandioller, Urska Repnik, Boris Turk, Christian G. Hartinger, Bernhard Keppler, Damijan Miklavcic, Iztok Turel
- Abstract
The thionated derivative of the antibacterial agent nalidixic acid and its organoruthenium complex were prepared, and their crystal structures were determined. The aqueous stability of the complex was studied and, unlike the case for the nalidixicato complex, increased stability of the ruthenium complex in aqueous solution was observed with only a minor degree of thionalidixicato ligand dissociated within 1 week. While the derivatization caused the antibacterial activity of the ligand against E. coli to decrease, the cytotcodcity of the complex against three cancer cell lines was significantly increased and the inhibitory potency against two enzymes of the cathepsin family was increased by 10-fold.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- University of Ljubljana, Jožef Stefan Institute (IJS), University of Auckland
- Journal
- Organometallics
- Volume
- 31
- Pages
- 5867-5874
- No. of pages
- 8
- ISSN
- 0276-7333
- DOI
- https://doi.org/10.1021/om300424w
- Publication date
- 2012
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104015 Organic chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/5cc6dfc1-b4c7-4a2b-88aa-f247497b03ef