Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- (X = P, As, or Ge)

Author(s): Tian Ma, Peng Yang, Inga Dammann, Zhengguo Lin, Ali S. Mougharbel, Ming-Xing Li, Florin Adasalitei, Raluca Mitea, Cristian Silvestru, Candice Thorstenson, Matthias S. Ullrich, Klaudia Cseh, Michael A. Jakupec, Bernhard K. Keppler, Manuela Donalisio, Roberta Cavalli, David Lembo, Ulrich Kortz
Abstract: We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)Sb III} 4(A-α-XW 9O 34) 2] n- [X = P V (1-P), As V (1-As), or Ge IV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).
Organisation(s): Department of Inorganic Chemistry
External organisation(s): Jacobs Universität Bremen, Babeș-Bolyai University, Shanghai University, University of Turin
Journal: Inorganic Chemistry
Volume: 59
Pages: 2978-2987
No. of pages: 10
ISSN: 0020-1669
DOI: https://doi.org/10.1021/acs.inorgchem.9b03322
Publication date: 03-2020
Peer reviewed: Yes
Austrian Fields of Science 2012: 104003 Inorganic chemistry
Keywords
ASJC Scopus subject areas: Inorganic Chemistry, Physical and Theoretical Chemistry
Sustainable Development Goals: SDG 3 - Good Health and Well-being
Portal url: https://ucrisportal.univie.ac.at/en/publications/5e5c9fb1-ff09-4c6a-a109-5d20054307a6

Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)Sb <sup>III</sup>} <sub>4</sub>(A-α-XW <sub>9</sub>O <sub>34</sub>) <sub>2</sub>] <sup>n-</sup> (X = P, As, or Ge)