Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallics
- Author(s)
- Margot N Wenzel, Samuel M Meier-Menches, Thomas L Williams, Eberard Rämisch, Giampaolo Barone, Angela Casini
- Abstract
The binding of Au(iii) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen.
- Organisation(s)
- External organisation(s)
- Cardiff University, Heraeus Noblelight Ltd., Università degli Studi di Palermo
- Journal
- Chemical Communications
- Volume
- 54
- Pages
- 611-614
- No. of pages
- 4
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/c7cc08406d
- Publication date
- 01-2018
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104002 Analytical chemistry
- ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials, General Chemistry, Ceramics and Composites, Metals and Alloys, Materials Chemistry, Surfaces, Coatings and Films, Catalysis
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/64e1be1f-54e1-467a-b33b-3762ce364a08