Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
- Author(s)
- Janos P. Meszaros, Heiko Geisler, Jelena M. Poljarevic, Alexander Roller, Maria S. Legina, Michaela Hejl, Michael A. Jakupec, Bernhard K. Keppler, Wolfgang Kandioller, Eva A. Enyedy
- Abstract
Half-sandwich organometallic complexes featuring Ru(II), Os(II) and Rh(III) metal centers and naturally occurring bidentate 2-hydroxy-[1,4]-naphthoquinone ligands (lawsone and phthiocol) have been synthesized and characterized in both solid state and solution phase by analytical, spectroscopic, electrochemical and single crystal X-ray diffraction techniques. Comparative studies revealed the influence of the respective metal center (Ru, Os, Rh), leaving group (Cl, Br, I) and arene (p-cymene, toluene, pentamethylcyclopentadienyl), as well as the naphthoquinone ligand on the structural properties and solution speciation. Additionally, cytotoxicity was tested in SW480, CH1/PA-1 and A549 human cancer cell lines showing a broad range of IC50 values. (C) 2019 Elsevier B.V. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry, Core Facility Crystal Structure Analysis
- External organisation(s)
- University of Szeged, University of Belgrade, University of Vienna
- Journal
- Journal of Organometallic Chemistry
- Volume
- 907
- No. of pages
- 10
- ISSN
- 0022-328X
- DOI
- https://doi.org/10.1016/j.jorganchem.2019.121070
- Publication date
- 02-2020
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104015 Organic chemistry
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, Biochemistry, Inorganic Chemistry, Physical and Theoretical Chemistry, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/6df81a22-75ee-462c-b7be-ec9b7edadd63