Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex)
- Author(s)
- Christian Kowol, Robert Trondl, Vladimir Arion, Michael Jakupec, Irene Lichtscheidl-Schultz, Bernhard Keppler
- Abstract
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- Dalton Transactions
- Volume
- 39
- Pages
- 704-706
- No. of pages
- 3
- ISSN
- 1477-9226
- DOI
- https://doi.org/10.1039/b919119b
- Publication date
- 2010
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 1040 Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/74f9da5e-1557-4f13-b3a9-8c9a0b344d2e