Theranostics with photodynamic therapy for personalized medicine: to see and to treat
- Author(s)
- Youchao Wang, Johannes Nikodemus Staudinger, Thomas L. Mindt, Gilles Gasser
- Abstract
Photodynamic Therapy (PDT) is an approved treatment modality, which is presently receiving great attention due to its limited invasiveness, high selectivity and limited susceptibility to drug resistance. Another related research area currently expanding rapidly is the development of novel theranostic agents based on the combination of PDT with different imaging technologies, which allows for both therapy and diagnosis. This combination can help to address issues of suboptimal biodistribution and selectivity through regional imaging, while therapeutic agents enable an effective and personalized therapy. In this review, we describe compounds, whose structures combine PDT photosensitizers with different imaging probes - including examples for near-infrared optical imaging, magnetic resonance imaging (MRI) and nuclear imaging (PET or SPECT), generating novel theranostic drug candidates. We have intentionally focused our attention on novel compounds, which have already been investigated preclinically in vivo in order to demonstrate the potential of such theranostic agents for clinical applications.
- Organisation(s)
- Department of Inorganic Chemistry, Joint Applied Medicinal Radiochemistry Facility
- External organisation(s)
- Chimie ParisTech, Université de recherche Paris Sciences et Lettres, Medizinische Universität Wien, Vienna Doctoral School in Chemistry (DoSChem)
- Journal
- Theranostics
- Volume
- 13
- Pages
- 5501-5544
- No. of pages
- 44
- ISSN
- 1838-7640
- DOI
- https://doi.org/10.7150/thno.87363
- Publication date
- 2023
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301306 Medical molecular biology, 301207 Pharmaceutical chemistry, 302054 Nuclear medicine
- Keywords
- ASJC Scopus subject areas
- Medicine (miscellaneous), Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/766531d6-1de7-48bf-89dc-d90269e77cef