18F fluoroethylations: different strategies for the rapid translation of 11C-methylated radiotracers
- Author(s)
- Wolfgang Wadsak, Leonhard-Key Mien, Dagmar E. Ettlinger, Harald Eidherr, Daniela Haeusler, Karoline Maria Sindelar, Bernhard Keppler, Robert Dudczak, Kurt Kletter, Markus Mitterhauser
- Abstract
Introduction: The translation of 11C-labeled compounds into their respective 18F-labeled derivatives is an important tool in the rapid development of positron emission tomography (PET) tracers. Thus, our aim was the development of a general method for the preparation of 18F-fluoroethylated compounds that (a) is applicable to a variety of precursors, (b) can be performed in a fully automated commercially available synthesizer and (c) enables this rapid translation of 11C-methylated tracers into their 18F-fluoroethylated analogs sharing the same precursor molecules. Methods: Ten methods for the preparation and purification of different 18F-fluoroethylating agents were compared. Subsequently, five 18F-labeled PET tracers were synthesized under fully automated conditions. Results: Radiochemical yields ranged from 34.4% to 60.8%, and time consumption ranged from 20 to 55 min for all methods. Use of 1-bromo-2-[18F]fluoroethane and distillation evinced as the method of choice. Conclusions: We were able to develop a general method for the preparation of a variety of 18F-fluoroethylated molecules. The provided tool is solely based on commercially available resources and has the potential to simplify and accelerate innovative PET tracer development in the future. © 2007 Elsevier Inc. All rights reserved.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien
- Journal
- Nuclear Medicine and Biology
- Volume
- 34
- Pages
- 1019-1028
- No. of pages
- 10
- ISSN
- 0969-8051
- DOI
- https://doi.org/10.1016/j.nucmedbio.2007.06.012
- Publication date
- 2007
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/7776875b-5aaf-4d93-b114-0b75f06312d9