New Iron(III)-Containing Composite of Salinomycinic Acid with Antitumor Activity—Synthesis and Characterization

Author(s)

Juliana Ivanova, Rositsa Kukeva, Radostina Stoyanova, Tanya Zhivkova, Abedulkadir Abudalleh, Lora Dyakova, Radostina Alexandrova, Irena Pashkunova-Martic, Johannes Theiner, Peter Dorkov, Michaela Hejl, Michael A. Jakupec, Bernhard Keppler, Ivo Grabchev

Abstract

In this study we demonstrated for the first time synthetic procedures for composites of salinomycin (SalH) and two-line ferrihydrite. The products were characterized by various methods such as elemental analysis, attenuated total reflectance–Fourier-transform spectroscopy (ATR-FTIR), electron paramagnetic resonance spectroscopy (EPR), powder X-ray diffraction analysis (XRD), electrospray-ionization mass spectrometry (ESI-MS), thermogravimetric analysis with differential thermal analysis (DTA) and mass spectrometry (TG-DTA/MS). The EPR spectra of the isolated compounds consisted of signals associated with both isolated Fe³⁺ ions and magnetically coupled Fe³⁺ ions. Powder XRD analyses of the isolated products showed two intense and broad peaks at 9° and 15° 2Θ, corresponding to salinomycinic acid. Broad peaks with very low intensity around 35°, assigned to two-line ferrihydrite, were also registered. Based on the experimental results, we concluded that salinomycin sodium reacted with Fe(III) chloride to form composites consisting of two-line ferrihydrite and salinomycinic acid. One of the composites exerted pronounced antitumor activity in the sub-micromolar concentration range against human cervical cancer (HeLa), non-small-cell lung cancer (A549), colon cancer (SW480), and ovarian teratocarcinoma (CH1/PA1) cells.

Organisation(s)

Department of Inorganic Chemistry, Microanalysis Services

External organisation(s)

Sofia University "St. Kliment Ohridski", Bulgarian Academy of Sciences (BAS), Medizinische Universität Wien, BIOVET JSC

Journal

Inorganics

Volume

12

ISSN

2304-6740

DOI

https://doi.org/10.3390/inorganics12080206

Publication date

08-2024

Peer reviewed

Yes

Austrian Fields of Science 2012

104003 Inorganic chemistry, 301904 Cancer research

Keywords

ASJC Scopus subject areas

Inorganic Chemistry

Sustainable Development Goals

SDG 3 - Good Health and Well-being

Portal url

https://ucrisportal.univie.ac.at/en/publications/7c688538-6f41-4bb1-9dee-cd6b922f01e9