Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects
- Author(s)
- Ulf-Peter Apfel, Christian Kowol, Yvonne Halpin, Florian Kloss, Joachim Kübel, Helmar Görls, Johannes G. Vos, Bernhard Keppler, Enrico Morera, Gino Lucente, Wolfgang Weigand
- Abstract
The present investigations deal with the modeling of the peptide surrounding of [FeFe] hydrogenase using amine containing disulphides to simulate possible influences of the amino acid lysine (K237) on the electrochemical and electrocatalytic properties of biomimetic compounds based on [Fe2S2] moieties. Fe3(CO)12 was reacted with Boc-4-amino-1,2-dithiolane, Boc-Adt-OMe (Adt = 4-amino-1,2-dithiolane-4-carboxylic acid, Boc = tert-butoxycarbonyl) and Boc-Adp tert-butyl ester (Adp = (S)-2-amino-3-(1,2-dithiolan-4-yl)propionic acid) to elongate the Fe?N distance in comparison to the well known [Fe2{(SCH2)2NR}(CO)6] model complexes. Efforts to deprotect the complexes containing Boc-4-amino-1,2-dithiolane with trifluoroacetic acid result in the formation of [Fe3(?3-O)(?-O2C2F3)6(OC4H8)2(H2O)]. The novel [2Fe2S] complexes are characterized using spectroscopic, electrochemical techniques and X-ray diffraction studies.
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- Friedrich-Schiller-Universität Jena, Dublin City University, Sapienza University of Rome
- Journal
- Journal of Inorganic Biochemistry
- Volume
- 103
- Pages
- 1236-1244
- No. of pages
- 9
- ISSN
- 0162-0134
- DOI
- https://doi.org/10.1016/j.jinorgbio.2009.07.005
- Publication date
- 2009
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 301305 Medical chemistry, 104002 Analytical chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/83a80180-c4d5-44b9-9620-e38d81ea32fb