Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 25 [1]. Synthesis of new imidazolyl and pyrazolyl derivatives of thiophene as inhibitors of nitric oxide synthase
- Author(s)
- Thomas Erker, Maria Galanski, Mathea Sophia Galanski
- Abstract
Some novel imidazolyl and pyrazolyl thiophene derivatives were synthesized. Different substituted N-containing heterocycles were chosen with the aim of enhancing the activity or selectivity of the products towards inhibition of one of the three isoforms of nitric oxide synthase. One series of substances was prepared by substitution reactions of 3-bromo-2-nitrothiophene with various heterocycles. In the other series introduction of a second heterocyclic substituent to pyrazolylthiophene compounds was attempted.
- Organisation(s)
- Department of Inorganic Chemistry
- Journal
- Journal of Heterocyclic Chemistry: international journal
- Volume
- 39
- Pages
- 857-861
- No. of pages
- 5
- ISSN
- 0022-152X
- Publication date
- 2002
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 3012 Pharmacy, Pharmacology, Toxicology
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/86961b09-cd47-46ef-81ec-98d4a1b3283e