Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations
- Author(s)
- Melanie Schmidlehner, Verena Pichler, Alexander Roller, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
- Abstract
Abstract Organometallic complexes with (thio)pyrone-based ligands have been shown to possess promising cytotoxic properties. To extend the class of potential metallodrugs, the (thio)pyrone backbone was modified via Mannich reaction with morpholine, N-methylpiperazine and piperidine as cyclic amine. The ligands and organometallic complexes were characterized by means of 1D and 2D NMR, ESI MS and also in one case by X-ray diffraction analysis. Due to the high aqueous solubility, the behavior and stability in aqueous solution of the synthesized complexes was studied by
1H NMR spectroscopy. In addition, the influence of these modifications on cytotoxicity in human cancer cell lines was investigated by means of the MTT assay.
- Organisation(s)
- Department of Inorganic Chemistry, Core Facility Crystal Structure Analysis
- Journal
- Journal of Organometallic Chemistry
- Volume
- 782
- Pages
- 69-76
- No. of pages
- 8
- ISSN
- 0022-328X
- DOI
- https://doi.org/10.1016/j.jorganchem.2014.10.044
- Publication date
- 04-2015
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104015 Organic chemistry
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, Biochemistry, Inorganic Chemistry, Physical and Theoretical Chemistry, Organic Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/87398e06-b24a-4cc7-bdc1-1718e8a6e002