Osmium(II)- versus ruthenium(II)-arene carbohydrate-based anticancer compounds: similarities and differences
- Author(s)
- Alexey Nazarov, Christian Hartinger, Wolfgang Kandioller, Michael Jakupec, Vladimir Arion, Paul J. Dyson, Bernhard Keppler
- Abstract
The synthesis and in vitro anticancer activity of OsII-arene complexes with carbohydrate-derived phosphite co-ligands are reported. The compounds were characterized by standard methods and the molecular structure of dichlorido(?6-p-cymene)(3,5,6-bicyclophosphite-1, 2-O-isopropylidene-?-d-glucofuranoside)osmium(ii) was determined by X-ray diffraction analysis. Complexes with chlorido leaving groups undergo hydrolysis by consecutive formation of aqua compounds, followed by cleavage of a P-O bond of sugar phosphite ligands, as demonstrated by NMR studies. These observations are similar to those of analogous RuII-arene complexes; however the rate of hydrolysis is very slow for osmium compounds. The complexes with oxalato leaving groups resist hydrolysis; no hydrolytic species were detected by 31P{1H} NMR spectroscopy over several days. Within this series of Os compounds, in vitro anticancer activity is highest for the most lipophilic chlorido complex dichlorido(?6-p-cymene)(3,5,6- bicyclophosphite-1,2-O-cyclohexylidene-?-d-glucofuranoside)osmium(ii).
- Organisation(s)
- Department of Inorganic Chemistry
- External organisation(s)
- École polytechnique fédérale de Lausanne
- Journal
- Dalton Transactions
- Volume
- 39
- Pages
- 7345-7352
- No. of pages
- 8
- ISSN
- 1477-9226
- DOI
- https://doi.org/10.1039/c003085f
- Publication date
- 2010
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/89b92422-ecc0-4848-8abd-7471407ec58f