On the binding modes of metal NHC complexes with DNA secondary structures: Implications for therapy and imaging
- Author(s)
- Özden Karaca, Samuel M. Meier-Menches, Angela Casini, Fritz E. Kühn
- Abstract
Organometallic compounds currently occupy an important place in the field of medicinal inorganic chemistry due to the unique chemical properties of metal coordination compounds. Particularly, metal compounds ligated by N-heterocyclic carbenes (NHC) have shown high potential for biomedical applications as antimicrobial and anticancer agents during the recent 15 years. Although further studies are necessary to validate the modes of action of this family of compounds, a number of biological targets have been identified, including DNA secondary structures. This perspective review aims at providing an overview of the most representative examples of metal NHC complexes reacting with nucleic acids via different binding modes. It is organized according to the type of DNA secondary structure targeted by metal NHCs, highlighting the possible advantages of biomedical applications, including therapy and imaging.
- Organisation(s)
- External organisation(s)
- Technische Universität München, Cardiff University
- Journal
- Chemical Communications
- Volume
- 53
- Pages
- 8249-8260
- No. of pages
- 12
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/c7cc03074f
- Publication date
- 2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 301303 Medical biochemistry, 104003 Inorganic chemistry, 301904 Cancer research
- ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials, Catalysis, Ceramics and Composites, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Materials Chemistry
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/9034fca7-d6a4-40f7-a8aa-cdcfeaae6849