Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes

Author(s)

Alexander Egger, Berta Cebrian, Iryna Stepanenko, Artem Krokhin, Rene Eichinger, Michael Jakupec, Vladimir Arion, Bernhard Keppler

Abstract

The antiproliferative properties of the osmium(II) complexes cis,fac-[Os Cl2(DMSO)3(L)] and

trans,cis,cis-[Os Cl2(DMSO)2(L)2](L¿1H-pyrazole, 1H-imidazole) were studied in three human

cancer cell lines, namely 41M (ovary), SK-BR-3 (breast), and SW480(colon). Their activities were

comparedwiththoseofosmium(III)andruthenium(III)NAMI-AtypecomplexesonHT-29(colon)and

SK-BR-3 cancer cell lines. While IC50 values of all the Os complexeswere found to be >1000mm in all

cell lines, Os and Ru-NAMI-A type complexes showed remarkable antiproliferative activity. The

marginal in vitro cytotoxicity of the Os compounds is presumably attributed to their resistance to

hydrolysis. However, the Os-NAMI-A complexes, which are also kinetically stable in aqueous solution,

showed reasonable antiproliferative activity in vitro when compared with the analogous Ru compounds

and with the Os -DMSO-azole species, indicating that hydrolysis might be not a prerequisite for the

antitumor activity of Os-NAMI-A type complexes.

Organisation(s)

Department of Inorganic Chemistry

Journal

Chemistry & Biodiversity

Volume

Pages

1588-1593

No. of pages

ISSN

1612-1872

Publication date

2008

Peer reviewed

Yes

Austrian Fields of Science 2012

104003 Inorganic chemistry

Sustainable Development Goals

SDG 3 - Good Health and Well-being

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