Geminal homologative fluorination of carbonyl derivatives <i>en route</i> to 1-fluoro-2-haloethyl skeletons
- Author(s)
- Margherita Miele, Davide Castiglione, Alexander Prado-Roller, Laura Castoldi, Vittorio Pace
- Abstract
Carbonyl groups undergo the sequential installation of two nucleophilic elements, halomethyl and fluoride moieties. This formal gem-difunctionalization enables the preparation-under full chemocontrol - of vic-fluorohaloethanes by simply defining the C1 nucleophile, thus enabling access to all combinations of the four halogens.
- Organisation(s)
- Core Facility Crystal Structure Analysis, Department of Inorganic Chemistry
- External organisation(s)
- University of Turin, Università degli Studi di Milano
- Journal
- Chemical Communications
- ISSN
- 1359-7345
- DOI
- https://doi.org/10.1039/d5cc01542a
- Publication date
- 06-2025
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104015 Organic chemistry
- ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials, General Chemistry, Ceramics and Composites, Metals and Alloys, Materials Chemistry, Surfaces, Coatings and Films, Catalysis
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/94563877-afe9-4fbb-8719-7216b2de295f