Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse
- Author(s)
- Amir Blazevic, Alfred A. Hummer, Petra Heffeter, Walter Berger, Martin Filipits, Giannantonio Cibin, Bernhard K. Keppler, Annette Rompel
- Abstract
Ruthenium complexes are promising candidates for anticancer agents, especially NKP-1339 (sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]), which is on the edge to clinical applications. The anticancer mechanism seems to be tightly linked to the redox chemistry but despite progress in human clinical trials the in vivo Ru oxidation state and the coordination of Ru remains unclear. The Ru-based anticancer drug NKP-1339 was studied applying XANES (Cl K-and Ru L
2,3-edges) in tumor, kidney and liver tissue of a SW480 bearing mouse. Based on coordination charge and 3D XANES plots containing a series of model compounds as well as pre-edge analysis of the ligand Cl K-edge it is suggested that NKP-1339 remains in its +III oxidation state after 24 hours and at least one of the four chlorido ligands remain covalently bound to the Ru ion showing a biotransformation from Ru
III N
2 Cl
4 to Ru
III Cl
x (N/O)
6-x (X = 1 or 2).
- Organisation(s)
- Department of Biophysical Chemistry, Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien, Diamond Light Source Ltd
- Journal
- Scientific Reports
- Volume
- 7
- No. of pages
- 8
- ISSN
- 2045-2322
- DOI
- https://doi.org/10.1038/srep40966
- Publication date
- 01-2017
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106006 Biophysics, 106002 Biochemistry
- Keywords
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/945bf1a5-805e-4740-b93b-9286d64f74e4