Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway
- Author(s)
- Lukas Scheibelberger, Toda Stankovic, Kaja Liepert, Andreas Kienzle, Eva Maria Patronas, Theresa Balber, Markus Mitterhauser, Arvand Haschemi, Katharina Pallitsch
- Abstract
Fluorinated carbohydrates are valuable tools for enzymological studies due to their increased metabolic stability compared to their non-fluorinated analogues. Replacing different hydroxyl groups within the same monosaccharide by fluorine allows to influence a wide range of sugar–receptor interactions and enzymatic transformations. In the past, this principle was frequently used to study the metabolism of highly abundant carbohydrates, while the metabolic fate of rare sugars is still poorly studied. Rare sugars, however, are key intermediates of many metabolic routes, such as the pentose phosphate pathway (PPP). Here we present the design and purely chemical synthesis of a set of three deoxyfluorinated analogues of the rare sugars d-xylulose and d-ribulose: 1-deoxy-1-fluoro-d-ribulose (1DFRu), 3-deoxy-3-fluoro-d-ribulose (3DFRu) and 3-deoxy-3-fluoro-d-xylulose (3DFXu). Together with a designed set of potential late-stage radio-fluorination precursors, they have the potential to become useful tools for studies on the complex equilibria of the non-oxidative PPP.
- Organisation(s)
- Department of Organic Chemistry, Department of Inorganic Chemistry
- External organisation(s)
- Medizinische Universität Wien, Ludwig Boltzmann Intitute Applied Diagnostics
- Journal
- European Journal of Organic Chemistry
- Volume
- 26
- ISSN
- 1434-193X
- DOI
- https://doi.org/10.1002/ejoc.202300339
- Publication date
- 08-2023
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104017 Physical chemistry, 104022 Theoretical chemistry, 104015 Organic chemistry
- Keywords
- ASJC Scopus subject areas
- Physical and Theoretical Chemistry, Organic Chemistry
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/a661bfeb-bda0-4a54-92ef-29ed9d4d27e9